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MiRNA-16-1 Suppresses Mcl-1 and Bcl-2 and Sensitizes Chronic Lymphocytic Leukemia Cells to BH3 Mimetic ABT-199

OBJECTIVE: Chronic lymphoid leukemia (CLL) is the most common type of leukemia among adults. Increased levels of Mcl-1 and Bcl-xL is linked to resistance to Bcl-2 inhibitors including ABT-199. In this study, we investigated the effect of miRNA-16-1 on apoptosis and sensitivity of the CLL cells to AB...

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Detalles Bibliográficos
Autores principales:	Ashofteh, Nooshin, Sayed Ali Mehbod, Amir, Bayat, Mohammad, Karami, Hadi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royan Institute 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468723/ https://www.ncbi.nlm.nih.gov/pubmed/36093807 http://dx.doi.org/10.22074/cellj.2022.8101

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