An optimized Factor H-Fc fusion protein against multidrug-resistant Neisseria gonorrhoeae

Novel therapeutics against the global threat of multidrug-resistant Neisseria gonorrhoeae are urgently needed. Gonococci evade killing by complement by binding factor H (FH), a key inhibitor of the alternative pathway. FH comprises 20 short consensus repeat (SCR) domains organized as a single chain....

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Detalles Bibliográficos
Autores principales: Shaughnessy, Jutamas, Chabeda, Aleyo, Tran, Y., Zheng, Bo, Nowak, Nancy, Steffens, Carolynn, DeOliveira, Rosane B., Gulati, Sunita, Lewis, Lisa A., Maclean, James, Moss, John A., Wycoff, Keith L., Ram, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468773/
https://www.ncbi.nlm.nih.gov/pubmed/36110842
http://dx.doi.org/10.3389/fimmu.2022.975676

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