Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here,...

Descripción completa

Detalles Bibliográficos
Autores principales: van Geffen, Chiel, Heiss, Constantin, Deißler, Astrid, Kolahian, Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468781/
https://www.ncbi.nlm.nih.gov/pubmed/36110844
http://dx.doi.org/10.3389/fimmu.2022.933847
_version_ 1784788493288865792
author van Geffen, Chiel
Heiss, Constantin
Deißler, Astrid
Kolahian, Saeed
author_facet van Geffen, Chiel
Heiss, Constantin
Deißler, Astrid
Kolahian, Saeed
author_sort van Geffen, Chiel
collection PubMed
description Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.
format Online
Article
Text
id pubmed-9468781
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94687812022-09-14 Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation van Geffen, Chiel Heiss, Constantin Deißler, Astrid Kolahian, Saeed Front Immunol Immunology Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468781/ /pubmed/36110844 http://dx.doi.org/10.3389/fimmu.2022.933847 Text en Copyright © 2022 van Geffen, Heiss, Deißler and Kolahian https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
van Geffen, Chiel
Heiss, Constantin
Deißler, Astrid
Kolahian, Saeed
Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
title Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
title_full Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
title_fullStr Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
title_full_unstemmed Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
title_short Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
title_sort pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468781/
https://www.ncbi.nlm.nih.gov/pubmed/36110844
http://dx.doi.org/10.3389/fimmu.2022.933847
work_keys_str_mv AT vangeffenchiel pharmacologicalmodulationofmyeloidderivedsuppressorcellstodampeninflammation
AT heissconstantin pharmacologicalmodulationofmyeloidderivedsuppressorcellstodampeninflammation
AT deißlerastrid pharmacologicalmodulationofmyeloidderivedsuppressorcellstodampeninflammation
AT kolahiansaeed pharmacologicalmodulationofmyeloidderivedsuppressorcellstodampeninflammation

Ejemplares similares