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Functional cure of a chronic virus infection by shifting the virus - host equilibrium state

The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotox...

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Detalles Bibliográficos
Autores principales: Bocharov, Gennady, Grebennikov, Dmitry, Cebollada Rica, Paula, Domenjo-Vila, Eva, Casella, Valentina, Meyerhans, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468810/
https://www.ncbi.nlm.nih.gov/pubmed/36110838
http://dx.doi.org/10.3389/fimmu.2022.904342
Descripción
Sumario:The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection.