Functional cure of a chronic virus infection by shifting the virus - host equilibrium state

The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotox...

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Autores principales: Bocharov, Gennady, Grebennikov, Dmitry, Cebollada Rica, Paula, Domenjo-Vila, Eva, Casella, Valentina, Meyerhans, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468810/
https://www.ncbi.nlm.nih.gov/pubmed/36110838
http://dx.doi.org/10.3389/fimmu.2022.904342
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author Bocharov, Gennady
Grebennikov, Dmitry
Cebollada Rica, Paula
Domenjo-Vila, Eva
Casella, Valentina
Meyerhans, Andreas
author_facet Bocharov, Gennady
Grebennikov, Dmitry
Cebollada Rica, Paula
Domenjo-Vila, Eva
Casella, Valentina
Meyerhans, Andreas
author_sort Bocharov, Gennady
collection PubMed
description The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection.
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spelling pubmed-94688102022-09-14 Functional cure of a chronic virus infection by shifting the virus - host equilibrium state Bocharov, Gennady Grebennikov, Dmitry Cebollada Rica, Paula Domenjo-Vila, Eva Casella, Valentina Meyerhans, Andreas Front Immunol Immunology The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468810/ /pubmed/36110838 http://dx.doi.org/10.3389/fimmu.2022.904342 Text en Copyright © 2022 Bocharov, Grebennikov, Cebollada Rica, Domenjo-Vila, Casella and Meyerhans https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bocharov, Gennady
Grebennikov, Dmitry
Cebollada Rica, Paula
Domenjo-Vila, Eva
Casella, Valentina
Meyerhans, Andreas
Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
title Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
title_full Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
title_fullStr Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
title_full_unstemmed Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
title_short Functional cure of a chronic virus infection by shifting the virus - host equilibrium state
title_sort functional cure of a chronic virus infection by shifting the virus - host equilibrium state
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468810/
https://www.ncbi.nlm.nih.gov/pubmed/36110838
http://dx.doi.org/10.3389/fimmu.2022.904342
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