Cargando…

Therapeutic and prognostic potential of GPCRs in prostate cancer from multi-omics landscape

Prostate cancer (PRAD) is a common and fatal malignancy. It is difficult to manage clinically due to drug resistance and poor prognosis, thus creating an urgent need for novel therapeutic targets and prognostic biomarkers. Although G protein-coupled receptors (GPCRs) have been most attractive for dr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shiqi, Chen, Jianfang, Chen, Xin, Yu, Jin, Guo, Yanzhi, Li, Menglong, Pu, Xuemei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468875/ https://www.ncbi.nlm.nih.gov/pubmed/36110544 http://dx.doi.org/10.3389/fphar.2022.997664

Ejemplares similares

Prediction of Synergistic Drug Combinations for Prostate Cancer by Transcriptomic and Network Characteristics
por: Li, Shiqi, et al.
Publicado: (2021)

Advancements in therapeutically targeting orphan GPCRs
por: Stockert, Jennifer A., et al.
Publicado: (2015)

A new molecular subclassification and in silico predictions for diagnosis and prognosis of papillary thyroid cancer by alternative splicing profile
por: Li, Haiyan, et al.
Publicado: (2023)

The therapeutic potential of orphan GPCRs, GPR35 and GPR55
por: Shore, Derek M., et al.
Publicado: (2015)

Probing the Druggablility on the Interface of the Protein–Protein Interaction and Its Allosteric Regulation Mechanism on the Drug Screening for the CXCR4 Homodimer
por: Shen, Liting, et al.
Publicado: (2019)

Multi-Omics Approach in the Identification of Potential Therapeutic Biomolecule for COVID-19
por: Singh, Rachana, et al.
Publicado: (2021)

Editorial: Orphan GPCRs As Emerging Drug Targets
por: Fang, Ye, et al.
Publicado: (2015)

Immune landscape-based machine-learning–assisted subclassification, prognosis, and immunotherapy prediction for glioblastoma
por: Li, Haiyan, et al.
Publicado: (2022)

Editorial: Monitoring endogenous GPCRs: lessons for drug design
por: Massotte, Dominique
Publicado: (2015)

The Impact of the Secondary Binding Pocket on the Pharmacology of Class A GPCRs
por: Egyed, Attila, et al.
Publicado: (2022)

Multi-omics approaches for in-depth understanding of therapeutic mechanism for Traditional Chinese Medicine
por: Zhu, Xue, et al.
Publicado: (2022)

Multi-omics analysis reveals CLIC1 as a therapeutic vulnerability of gliomas
por: Wang, Chengcheng, et al.
Publicado: (2023)

Multi-Omics Approach to Dissect the Mechanisms of Rexinoid Signaling in Myoblast Differentiation
por: Khilji, Saadia, et al.
Publicado: (2021)

Constructing a cancer stem cell related prognostic model for predicting immune landscape and drug sensitivity in colorectal cancer
por: Chen, Jianfang, et al.
Publicado: (2023)

Title: Multi-Omics and Immune Landscape of Proliferative LncRNA Signatures: Implications for Risk Stratification and Immunotherapy in Hepatocellular Carcinoma
por: Liu, Chi, et al.
Publicado: (2022)

Editorial: Multi-omics approaches for decoding heterogeneity in cancer immunotherapy
por: Jiang, Aimin, et al.
Publicado: (2023)

Using omics approaches to dissect the therapeutic effects of Chinese herbal medicines on gastrointestinal cancers
por: Li, Si-Yi, et al.
Publicado: (2022)

Identification of Hub lncRNAs Along With lncRNA-miRNA-mRNA Network for Effective Diagnosis and Prognosis of Papillary Thyroid Cancer
por: Li, Haiyan, et al.
Publicado: (2021)

Osteosarcoma Multi-Omics Landscape and Subtypes
por: Tang, Shan, et al.
Publicado: (2023)

Editorial: Biomolecules Against Coronaviruses: Molecular Aspects, Multi-Omics and Systems Pharmacology
por: Hano, Christophe, et al.
Publicado: (2022)

Dissecting the regulation rules of cancer-related miRNAs based on network analysis
por: Liu, Zhongyu, et al.
Publicado: (2016)

Comparative Analysis for the Performance of Variant Calling Pipelines on Detecting the de novo Mutations in Humans
por: Liang, Yu, et al.
Publicado: (2019)

Identification of prognostic and diagnostic signatures for cancer and acute myocardial infarction: multi-omics approaches for deciphering heterogeneity to enhance patient management
por: Yuan, Na, et al.
Publicado: (2023)

Decoding tumor heterogeneity in uveal melanoma: basement membrane genes as novel biomarkers and therapeutic targets revealed by multi-omics approaches for cancer immunotherapy
por: Li, Yunyue, et al.
Publicado: (2023)

Novel Therapeutic GPCRs for Psychiatric Disorders
por: Komatsu, Hidetoshi
Publicado: (2015)

Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain
por: Retamal, Jeffri S., et al.
Publicado: (2019)

The Prognostic and Therapeutic Value of PD-L1 in Glioma
por: Chen, Ruo Qiao, et al.
Publicado: (2019)

Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance
por: Zheng, Kun, et al.
Publicado: (2023)

Editorial: Antidepressant mechanisms of natural products based on multi-omics technologies
por: Fang, Yichao, et al.
Publicado: (2023)

Crosstalk between G protein-coupled receptors (GPCRs) and tyrosine kinase receptor (TXR) in the heart after morphine withdrawal
por: Almela, Pilar, et al.
Publicado: (2013)

Exploring G Protein-Coupled Receptors (GPCRs) Ligand Space via Cheminformatics Approaches: Impact on Rational Drug Design
por: Basith, Shaherin, et al.
Publicado: (2018)

Multi-Omics Reveals Inhibitory Effect of Baicalein on Non-Alcoholic Fatty Liver Disease in Mice
por: Li, Ping, et al.
Publicado: (2022)

Therapeutic Applications of Functional Nanomaterials for Prostatitis
por: Liu, Chun-Ping, et al.
Publicado: (2021)

Effective Identification of Gram-Negative Bacterial Type III Secreted Effectors Using Position-Specific Residue Conservation Profiles
por: Yang, Xiaojiao, et al.
Publicado: (2013)

Functional dissection of human targets for KSHV-encoded miRNAs using network analysis
por: Wang, Yu, et al.
Publicado: (2017)

A structural dissection of protein–RNA interactions based on different RNA base areas of interfaces
por: Hu, Wen, et al.
Publicado: (2018)

A Transfer-Learning-Based Deep Convolutional Neural Network for Predicting Leukemia-Related Phosphorylation Sites from Protein Primary Sequences
por: He, Jian, et al.
Publicado: (2022)

The Mutational, Prognostic, and Therapeutic Landscape of Neuroendocrine Neoplasms
por: Liu, Man, et al.
Publicado: (2023)

Editorial: GPCRs and Cancer
por: Chen, Suzie
Publicado: (2017)

Identification of angiogenesis-related subtypes, the development of prognostic models, and the landscape of tumor microenvironment infiltration in colorectal cancer
por: Zhang, Chen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_odo49dn03gqqn1ojjs94gbkk6h