The role of B cells in COVID-19 infection and vaccination

B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SAR...

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Detalles Bibliográficos
Autores principales: Chen, Shiru, Guan, Fei, Candotti, Fabio, Benlagha, Kamel, Camara, Niels Olsen Saraiva, Herrada, Andres A., James, Louisa K., Lei, Jiahui, Miller, Heather, Kubo, Masato, Ning, Qin, Liu, Chaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468879/
https://www.ncbi.nlm.nih.gov/pubmed/36110861
http://dx.doi.org/10.3389/fimmu.2022.988536
Descripción
Sumario:B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.

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