The role of B cells in COVID-19 infection and vaccination

B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SAR...

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Autores principales: Chen, Shiru, Guan, Fei, Candotti, Fabio, Benlagha, Kamel, Camara, Niels Olsen Saraiva, Herrada, Andres A., James, Louisa K., Lei, Jiahui, Miller, Heather, Kubo, Masato, Ning, Qin, Liu, Chaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468879/
https://www.ncbi.nlm.nih.gov/pubmed/36110861
http://dx.doi.org/10.3389/fimmu.2022.988536
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author Chen, Shiru
Guan, Fei
Candotti, Fabio
Benlagha, Kamel
Camara, Niels Olsen Saraiva
Herrada, Andres A.
James, Louisa K.
Lei, Jiahui
Miller, Heather
Kubo, Masato
Ning, Qin
Liu, Chaohong
author_facet Chen, Shiru
Guan, Fei
Candotti, Fabio
Benlagha, Kamel
Camara, Niels Olsen Saraiva
Herrada, Andres A.
James, Louisa K.
Lei, Jiahui
Miller, Heather
Kubo, Masato
Ning, Qin
Liu, Chaohong
author_sort Chen, Shiru
collection PubMed
description B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.
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spelling pubmed-94688792022-09-14 The role of B cells in COVID-19 infection and vaccination Chen, Shiru Guan, Fei Candotti, Fabio Benlagha, Kamel Camara, Niels Olsen Saraiva Herrada, Andres A. James, Louisa K. Lei, Jiahui Miller, Heather Kubo, Masato Ning, Qin Liu, Chaohong Front Immunol Immunology B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468879/ /pubmed/36110861 http://dx.doi.org/10.3389/fimmu.2022.988536 Text en Copyright © 2022 Chen, Guan, Candotti, Benlagha, Camara, Herrada, James, Lei, Miller, Kubo, Ning and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Shiru
Guan, Fei
Candotti, Fabio
Benlagha, Kamel
Camara, Niels Olsen Saraiva
Herrada, Andres A.
James, Louisa K.
Lei, Jiahui
Miller, Heather
Kubo, Masato
Ning, Qin
Liu, Chaohong
The role of B cells in COVID-19 infection and vaccination
title The role of B cells in COVID-19 infection and vaccination
title_full The role of B cells in COVID-19 infection and vaccination
title_fullStr The role of B cells in COVID-19 infection and vaccination
title_full_unstemmed The role of B cells in COVID-19 infection and vaccination
title_short The role of B cells in COVID-19 infection and vaccination
title_sort role of b cells in covid-19 infection and vaccination
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468879/
https://www.ncbi.nlm.nih.gov/pubmed/36110861
http://dx.doi.org/10.3389/fimmu.2022.988536
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