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A deep learning-based automatic staging method for early endometrial cancer on MRI images

Early treatment increases the 5-year survival rate of patients with endometrial cancer (EC). Deep learning (DL) as a new computer-aided diagnosis method has been widely used in medical image processing which can reduce the misdiagnosis by radiologists. An automatic staging method based on DL for the...

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Autores principales: Mao, Wei, Chen, Chunxia, Gao, Huachao, Xiong, Liu, Lin, Yongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468895/
https://www.ncbi.nlm.nih.gov/pubmed/36111158
http://dx.doi.org/10.3389/fphys.2022.974245
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author Mao, Wei
Chen, Chunxia
Gao, Huachao
Xiong, Liu
Lin, Yongping
author_facet Mao, Wei
Chen, Chunxia
Gao, Huachao
Xiong, Liu
Lin, Yongping
author_sort Mao, Wei
collection PubMed
description Early treatment increases the 5-year survival rate of patients with endometrial cancer (EC). Deep learning (DL) as a new computer-aided diagnosis method has been widely used in medical image processing which can reduce the misdiagnosis by radiologists. An automatic staging method based on DL for the early diagnosis of EC will benefit both radiologists and patients. To develop an effective and automatic prediction model for early EC diagnosis on magnetic resonance imaging (MRI) images, we retrospectively enrolled 117 patients (73 of stage IA, 44 of stage IB) with a pathological diagnosis of early EC confirmed by postoperative biopsy at our institution from 1 January 2018, to 31 December 2020. Axial T2-weighted image (T2WI), axial diffusion-weighted image (DWI) and sagittal T2WI images from 117 patients have been classified into stage IA and stage IB according to the patient’s pathological diagnosis. Firstly, a semantic segmentation model based on the U-net network is trained to segment the uterine region and the tumor region on the MRI images. Then, the area ratio of the tumor region to the uterine region (TUR) in the segmentation map is calculated. Finally, the receiver operating characteristic curves (ROCs) are plotted by the TUR and the results of the patient’s pathological diagnosis in the test set to find the optimal staging thresholds for stage IA and stage IB. In the test sets, the trained semantic segmentation model yields the average Dice similarity coefficients of uterus and tumor on axial T2WI, axial DWI, and sagittal T2WI were 0.958 and 0.917, 0.956 and 0.941, 0.972 and 0.910 respectively. With pathological diagnostic results as the gold standard, the classification model on axial T2WI, axial DWI, and sagittal T2WI yielded an area under the curve (AUC) of 0.86, 0.85 and 0.94, respectively. In this study, an automatic DL-based segmentation model combining the ROC analysis of TUR on MRI images presents an effective early EC staging method.
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spelling pubmed-94688952022-09-14 A deep learning-based automatic staging method for early endometrial cancer on MRI images Mao, Wei Chen, Chunxia Gao, Huachao Xiong, Liu Lin, Yongping Front Physiol Physiology Early treatment increases the 5-year survival rate of patients with endometrial cancer (EC). Deep learning (DL) as a new computer-aided diagnosis method has been widely used in medical image processing which can reduce the misdiagnosis by radiologists. An automatic staging method based on DL for the early diagnosis of EC will benefit both radiologists and patients. To develop an effective and automatic prediction model for early EC diagnosis on magnetic resonance imaging (MRI) images, we retrospectively enrolled 117 patients (73 of stage IA, 44 of stage IB) with a pathological diagnosis of early EC confirmed by postoperative biopsy at our institution from 1 January 2018, to 31 December 2020. Axial T2-weighted image (T2WI), axial diffusion-weighted image (DWI) and sagittal T2WI images from 117 patients have been classified into stage IA and stage IB according to the patient’s pathological diagnosis. Firstly, a semantic segmentation model based on the U-net network is trained to segment the uterine region and the tumor region on the MRI images. Then, the area ratio of the tumor region to the uterine region (TUR) in the segmentation map is calculated. Finally, the receiver operating characteristic curves (ROCs) are plotted by the TUR and the results of the patient’s pathological diagnosis in the test set to find the optimal staging thresholds for stage IA and stage IB. In the test sets, the trained semantic segmentation model yields the average Dice similarity coefficients of uterus and tumor on axial T2WI, axial DWI, and sagittal T2WI were 0.958 and 0.917, 0.956 and 0.941, 0.972 and 0.910 respectively. With pathological diagnostic results as the gold standard, the classification model on axial T2WI, axial DWI, and sagittal T2WI yielded an area under the curve (AUC) of 0.86, 0.85 and 0.94, respectively. In this study, an automatic DL-based segmentation model combining the ROC analysis of TUR on MRI images presents an effective early EC staging method. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468895/ /pubmed/36111158 http://dx.doi.org/10.3389/fphys.2022.974245 Text en Copyright © 2022 Mao, Chen, Gao, Xiong and Lin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Mao, Wei
Chen, Chunxia
Gao, Huachao
Xiong, Liu
Lin, Yongping
A deep learning-based automatic staging method for early endometrial cancer on MRI images
title A deep learning-based automatic staging method for early endometrial cancer on MRI images
title_full A deep learning-based automatic staging method for early endometrial cancer on MRI images
title_fullStr A deep learning-based automatic staging method for early endometrial cancer on MRI images
title_full_unstemmed A deep learning-based automatic staging method for early endometrial cancer on MRI images
title_short A deep learning-based automatic staging method for early endometrial cancer on MRI images
title_sort deep learning-based automatic staging method for early endometrial cancer on mri images
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468895/
https://www.ncbi.nlm.nih.gov/pubmed/36111158
http://dx.doi.org/10.3389/fphys.2022.974245
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