Sirtuins functions in central nervous system cells under neurological disorders

The sirtuins (SIRTs), a class of NAD+ -dependent deacylases, contain seven SIRT family members in mammals, from SIRT1 to SIRT7. Extensive studies have revealed that SIRT proteins regulate virous cell functions. Central nervous system (CNS) decline resulted in progressive cognitive impairment, social...

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Autores principales: Yan, Jing, Tang, Xiaole, Zhou, Zhi-qiang, Zhang, Jie, Zhao, Yilin, Li, Shiyong, Luo, Ailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468898/
https://www.ncbi.nlm.nih.gov/pubmed/36111151
http://dx.doi.org/10.3389/fphys.2022.886087
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author Yan, Jing
Tang, Xiaole
Zhou, Zhi-qiang
Zhang, Jie
Zhao, Yilin
Li, Shiyong
Luo, Ailin
author_facet Yan, Jing
Tang, Xiaole
Zhou, Zhi-qiang
Zhang, Jie
Zhao, Yilin
Li, Shiyong
Luo, Ailin
author_sort Yan, Jing
collection PubMed
description The sirtuins (SIRTs), a class of NAD+ -dependent deacylases, contain seven SIRT family members in mammals, from SIRT1 to SIRT7. Extensive studies have revealed that SIRT proteins regulate virous cell functions. Central nervous system (CNS) decline resulted in progressive cognitive impairment, social and physical abilities dysfunction. Therefore, it is of vital importance to have a better understanding of potential target to promote homeostasis of CNS. SIRTs have merged as the underlying regulating factors of the process of neurological disorders. In this review, we profile multiple functions of SIRT proteins in different cells during brain function and under CNS injury.
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spelling pubmed-94688982022-09-14 Sirtuins functions in central nervous system cells under neurological disorders Yan, Jing Tang, Xiaole Zhou, Zhi-qiang Zhang, Jie Zhao, Yilin Li, Shiyong Luo, Ailin Front Physiol Physiology The sirtuins (SIRTs), a class of NAD+ -dependent deacylases, contain seven SIRT family members in mammals, from SIRT1 to SIRT7. Extensive studies have revealed that SIRT proteins regulate virous cell functions. Central nervous system (CNS) decline resulted in progressive cognitive impairment, social and physical abilities dysfunction. Therefore, it is of vital importance to have a better understanding of potential target to promote homeostasis of CNS. SIRTs have merged as the underlying regulating factors of the process of neurological disorders. In this review, we profile multiple functions of SIRT proteins in different cells during brain function and under CNS injury. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9468898/ /pubmed/36111151 http://dx.doi.org/10.3389/fphys.2022.886087 Text en Copyright © 2022 Yan, Tang, Zhou, Zhang, Zhao, Li and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Yan, Jing
Tang, Xiaole
Zhou, Zhi-qiang
Zhang, Jie
Zhao, Yilin
Li, Shiyong
Luo, Ailin
Sirtuins functions in central nervous system cells under neurological disorders
title Sirtuins functions in central nervous system cells under neurological disorders
title_full Sirtuins functions in central nervous system cells under neurological disorders
title_fullStr Sirtuins functions in central nervous system cells under neurological disorders
title_full_unstemmed Sirtuins functions in central nervous system cells under neurological disorders
title_short Sirtuins functions in central nervous system cells under neurological disorders
title_sort sirtuins functions in central nervous system cells under neurological disorders
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468898/
https://www.ncbi.nlm.nih.gov/pubmed/36111151
http://dx.doi.org/10.3389/fphys.2022.886087
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