A Codispersed Nanosystem of Silver-anchored MoS(2) Enhances Antibacterial and Antitumor Properties of Selective Laser Sintered Scaffolds

Tumor recurrence and bacterial infection are common problems during bone repair and reconstruction after bone tumor surgery. In this study, silver-anchored MoS(2) nanosheets (Ag@PMoS(2)) were synthesized by in situ reduction, then a composite polymer scaffold (Ag@PMoS(2)/PGA) with sustained antitumor and antibacterial activity was successfully constructed by selective laser sintering technique. In the Ag@PMoS(2) nanostructures, silver nanoparticles (Ag NPs) were sandwiched between adjacent MoS(2) nanosheets (MoS(2) NSs), which restrained the restacking of the MoS(2) NSs. In addition, the MoS(2) NSs acted as steric hindrance layers, which prevented the aggregation of Ag NPs. More importantly, MoS(2) NSs can provide a barrier layer for Ag NPs, hindering Ag NPs from reacting with the external solution to prevent its quick release. The results showed that Ag@PMoS(2)/PGA scaffolds have stronger photothermal effect and antitumor function. Meanwhile, the Ag@PMoS(2)/PGA scaffolds also demonstrated slow control of silver ion (Ag(+)) release and more efficient long-term antibacterial ability. Besides, composite scaffolds have been proved to kill the MG-63 cells by inducing apoptosis and inhibit bacterial proliferation by upregulating the level of bacterial reactive oxygen species. This kind of novel bifunctional implants with antitumor and antibacterial properties provides better choice for the artificial bone transplantation after primary bone tumor resection.