Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis–Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes

Mycotoxins, fungal secondary metabolites, are ubiquitously present in food commodities. Acute exposure to high levels or chronic exposure to low levels has an impact on the human body. The phase I metabolism in the human liver, performed by cytochrome P450 (CYP450) enzymes, is accountable for more t...

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Detalles Bibliográficos
Autores principales: Lootens, Orphélie, De Boevre, Marthe, Gasthuys, Elke, Van Bocxlaer, Jan, Vermeulen, An, De Saeger, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469084/
https://www.ncbi.nlm.nih.gov/pubmed/36110298
http://dx.doi.org/10.3389/fmicb.2022.988083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469084/
https://www.ncbi.nlm.nih.gov/pubmed/36110298
http://dx.doi.org/10.3389/fmicb.2022.988083

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