Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach

[Image: see text] Protein arginine methyltransferases (PRMTs) are important therapeutic targets, playing a crucial role in the regulation of many cellular processes and being linked to many diseases. Yet, there is still much to be understood regarding their functions and the biological pathways in w...

Descripción completa

Detalles Bibliográficos
Autores principales: Iannelli, Giulia, Milite, Ciro, Marechal, Nils, Cura, Vincent, Bonnefond, Luc, Troffer-Charlier, Nathalie, Feoli, Alessandra, Rescigno, Donatella, Wang, Yalong, Cipriano, Alessandra, Viviano, Monica, Bedford, Mark T., Cavarelli, Jean, Castellano, Sabrina, Sbardella, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469100/
https://www.ncbi.nlm.nih.gov/pubmed/35482954
http://dx.doi.org/10.1021/acs.jmedchem.2c00252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469100/
https://www.ncbi.nlm.nih.gov/pubmed/35482954
http://dx.doi.org/10.1021/acs.jmedchem.2c00252

Ejemplares similares