Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia

OBJECTIVES: To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia. MATERIALS AND METHODS: In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400...

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Autores principales: Manas, Abhigyan, Venkateswararao, CH, Vaid, Shivali, Dhakray Khanna, Vidhi, Muhaseena, M, Alvi, Sadaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469266/
https://www.ncbi.nlm.nih.gov/pubmed/36110830
http://dx.doi.org/10.4103/jpbs.jpbs_63_22
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author Manas, Abhigyan
Venkateswararao, CH
Vaid, Shivali
Dhakray Khanna, Vidhi
Muhaseena, M
Alvi, Sadaf
author_facet Manas, Abhigyan
Venkateswararao, CH
Vaid, Shivali
Dhakray Khanna, Vidhi
Muhaseena, M
Alvi, Sadaf
author_sort Manas, Abhigyan
collection PubMed
description OBJECTIVES: To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia. MATERIALS AND METHODS: In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400 I.U. of vitamin E, and 200 μg of selenium twice a day. Group II patients were prescribed a placebo capsule. The clinical improvement was recorded in both groups. RESULTS: The mean pretreatment size of lesion in group I was 9.24 cm(2) and in group II was 8.52 cm(2). Post treatment size was 1.52 cm(2) in group I and 6.28 cm(2) in group II. There was a significant reduction in the size of lesion in group I compared to group II (P < 0.05). CONCLUSION: The treatment with a combination of lycopene, selenium, and vitamin E is useful and effective in managing the cases of oral leukoplakia.
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spelling pubmed-94692662022-09-14 Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia Manas, Abhigyan Venkateswararao, CH Vaid, Shivali Dhakray Khanna, Vidhi Muhaseena, M Alvi, Sadaf J Pharm Bioallied Sci Original Article OBJECTIVES: To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia. MATERIALS AND METHODS: In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400 I.U. of vitamin E, and 200 μg of selenium twice a day. Group II patients were prescribed a placebo capsule. The clinical improvement was recorded in both groups. RESULTS: The mean pretreatment size of lesion in group I was 9.24 cm(2) and in group II was 8.52 cm(2). Post treatment size was 1.52 cm(2) in group I and 6.28 cm(2) in group II. There was a significant reduction in the size of lesion in group I compared to group II (P < 0.05). CONCLUSION: The treatment with a combination of lycopene, selenium, and vitamin E is useful and effective in managing the cases of oral leukoplakia. Wolters Kluwer - Medknow 2022-07 2022-07-13 /pmc/articles/PMC9469266/ /pubmed/36110830 http://dx.doi.org/10.4103/jpbs.jpbs_63_22 Text en Copyright: © 2022 Journal of Pharmacy and Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Manas, Abhigyan
Venkateswararao, CH
Vaid, Shivali
Dhakray Khanna, Vidhi
Muhaseena, M
Alvi, Sadaf
Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia
title Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia
title_full Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia
title_fullStr Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia
title_full_unstemmed Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia
title_short Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia
title_sort assessment of utility of lycopene, selenium, and vitamin e in management of oral leukoplakia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469266/
https://www.ncbi.nlm.nih.gov/pubmed/36110830
http://dx.doi.org/10.4103/jpbs.jpbs_63_22
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