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A Surgical Approach in the Management of Mucormycosis in Trauma Patients

INTRODUCTION: Fungal infections are rare occurrence in the oral cavity. They are most often seen in other medical conditions such as the immunocompromised states, diabetes, on immunosuppressants, and more recently, among the COVID patients. There are various ways that are employed to manage these in...

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Autores principales: Singh, Karn, Jyothirmayee, K., Rani, Ruma, Vamshi, N. Surya, Francis, Mariea, Nath, Anagha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469285/
https://www.ncbi.nlm.nih.gov/pubmed/36110681
http://dx.doi.org/10.4103/jpbs.jpbs_103_22
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author Singh, Karn
Jyothirmayee, K.
Rani, Ruma
Vamshi, N. Surya
Francis, Mariea
Nath, Anagha S.
author_facet Singh, Karn
Jyothirmayee, K.
Rani, Ruma
Vamshi, N. Surya
Francis, Mariea
Nath, Anagha S.
author_sort Singh, Karn
collection PubMed
description INTRODUCTION: Fungal infections are rare occurrence in the oral cavity. They are most often seen in other medical conditions such as the immunocompromised states, diabetes, on immunosuppressants, and more recently, among the COVID patients. There are various ways that are employed to manage these infections. The most usual of fungal infection in these conditions is mucormycosis, also called as zygomycosis. Hence, in our study, we aim to evaluate the management of the fungal infection mucormycosis in trauma patients by the surgical approach. MATERIALS AND METHODS: We piloted a retrospective observational study among 50 subjects who were admitted to the department with oral fungal infections with mucormycosis. We analyzed various clinical and demographic parameters among the subjects. The data thus obtained were analyzed with proper statistical tools deliberating P < 0.05 as significant. RESULTS: We observed that among the 50 subjects, the mean age was 41 ± 1.7 years. There was no significant difference between the genders and the age groups. The most common reason for the oral involvement was uncontrolled diabetes. This was followed by malignancy, specifically leukemia, AIDS, and COVID. The most common site of the involvement was the palate, followed by the mandibular region. All the subjects tested positive for the fungal hyphae of Rhizopus arrhizus which was the most common of the species. The surgical debridement along with the medical management showed satisfactory results, while one death was noted in our study. CONCLUSION: Although rare, oral involvement in the fungal infection with the mucormycosis is often easily managed when diagnosed early. The proper surgical debridement is the best method of treatment along with the appropriate medications. The management of the underlying medical conditions is the primary key for the success of the treatments.
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spelling pubmed-94692852022-09-14 A Surgical Approach in the Management of Mucormycosis in Trauma Patients Singh, Karn Jyothirmayee, K. Rani, Ruma Vamshi, N. Surya Francis, Mariea Nath, Anagha S. J Pharm Bioallied Sci Original Article INTRODUCTION: Fungal infections are rare occurrence in the oral cavity. They are most often seen in other medical conditions such as the immunocompromised states, diabetes, on immunosuppressants, and more recently, among the COVID patients. There are various ways that are employed to manage these infections. The most usual of fungal infection in these conditions is mucormycosis, also called as zygomycosis. Hence, in our study, we aim to evaluate the management of the fungal infection mucormycosis in trauma patients by the surgical approach. MATERIALS AND METHODS: We piloted a retrospective observational study among 50 subjects who were admitted to the department with oral fungal infections with mucormycosis. We analyzed various clinical and demographic parameters among the subjects. The data thus obtained were analyzed with proper statistical tools deliberating P < 0.05 as significant. RESULTS: We observed that among the 50 subjects, the mean age was 41 ± 1.7 years. There was no significant difference between the genders and the age groups. The most common reason for the oral involvement was uncontrolled diabetes. This was followed by malignancy, specifically leukemia, AIDS, and COVID. The most common site of the involvement was the palate, followed by the mandibular region. All the subjects tested positive for the fungal hyphae of Rhizopus arrhizus which was the most common of the species. The surgical debridement along with the medical management showed satisfactory results, while one death was noted in our study. CONCLUSION: Although rare, oral involvement in the fungal infection with the mucormycosis is often easily managed when diagnosed early. The proper surgical debridement is the best method of treatment along with the appropriate medications. The management of the underlying medical conditions is the primary key for the success of the treatments. Wolters Kluwer - Medknow 2022-07 2022-07-13 /pmc/articles/PMC9469285/ /pubmed/36110681 http://dx.doi.org/10.4103/jpbs.jpbs_103_22 Text en Copyright: © 2022 Journal of Pharmacy and Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Singh, Karn
Jyothirmayee, K.
Rani, Ruma
Vamshi, N. Surya
Francis, Mariea
Nath, Anagha S.
A Surgical Approach in the Management of Mucormycosis in Trauma Patients
title A Surgical Approach in the Management of Mucormycosis in Trauma Patients
title_full A Surgical Approach in the Management of Mucormycosis in Trauma Patients
title_fullStr A Surgical Approach in the Management of Mucormycosis in Trauma Patients
title_full_unstemmed A Surgical Approach in the Management of Mucormycosis in Trauma Patients
title_short A Surgical Approach in the Management of Mucormycosis in Trauma Patients
title_sort surgical approach in the management of mucormycosis in trauma patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469285/
https://www.ncbi.nlm.nih.gov/pubmed/36110681
http://dx.doi.org/10.4103/jpbs.jpbs_103_22
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