Success Rate of Growth Factors for Existing Periapical Lesions in Failed Endodontically Treated Teeth in Adult Population: A Systematic Review and Meta-Analysis

INTRODUCTION: In this study, we investigated the success rate of growth factors for existing periapical lesions in failed endodontically treated teeth in an adult population by systematic review and meta-analysis. MATERIALS AND METHODS: We conducted an online data search based on preferred reporting items for systematic reviews and meta analyses (PRISMA), from databases PUBMED, MEDLINE, and EMBASE, for the application of various types of growth factors in endodontically failed teeth with periapical lesions in adults. These included the “platelet-rich plasma (PRP) and platelet-rich fibrin (PRF),” blood, etc. The data were meta-analyzed using MetaXL 5.3, and GRADE was used to assess the certainty. RESULTS: We observed that success of 0.95 was achieved by the end of a year's follow-up with the application of growth factors for periodontal lesions. We also observed that the teeth responded to thermal tests, indicating regeneration; however, studies were with bias and lower sensitivity. DISCUSSION: \ Similar to regeneration in immature teeth, growth factors also showed greater success in the treatment of periapical lesions in the failed endodontic teeth in adults.