A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus‐like Disease in Mice

OBJECTIVE: To determine if single‐nucleotide polymorphisms (SNPs) in DNA repair genes are enriched in individuals with systemic lupus erythematosus (SLE) and if they are sufficient to confer a disease phenotype in a mouse model. METHODS: Human exome chip data of 2499 patients with SLE and 1230 healt...

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Detalles Bibliográficos
Autores principales: Meas, Rithy, Nititham, Joanne, Taylor, Kimberly E., Maher, Stephen, Clairmont, Kaylyn, Carufe, Kelly E. W., Kashgarian, Michael, Nottoli, Timothy, Cheong, Ana, Nagel, Zachary D., Gaffney, Patrick M., Criswell, Lindsey A., Sweasy, Joann B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469486/
https://www.ncbi.nlm.nih.gov/pubmed/35708944
http://dx.doi.org/10.1002/acr2.11471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469486/
https://www.ncbi.nlm.nih.gov/pubmed/35708944
http://dx.doi.org/10.1002/acr2.11471

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