TRIM proteins in hepatocellular carcinoma

The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasom...

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Autores principales: Lu, Kan, Pan, Yonglong, Huang, Zhao, Liang, Huifang, Ding, Ze-yang, Zhang, Bixiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469581/
https://www.ncbi.nlm.nih.gov/pubmed/36100865
http://dx.doi.org/10.1186/s12929-022-00854-7
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author Lu, Kan
Pan, Yonglong
Huang, Zhao
Liang, Huifang
Ding, Ze-yang
Zhang, Bixiang
author_facet Lu, Kan
Pan, Yonglong
Huang, Zhao
Liang, Huifang
Ding, Ze-yang
Zhang, Bixiang
author_sort Lu, Kan
collection PubMed
description The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM proteins in HCC and helps us better understand the molecular mechanism of the development and progression of HCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12929-022-00854-7.
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spelling pubmed-94695812022-09-14 TRIM proteins in hepatocellular carcinoma Lu, Kan Pan, Yonglong Huang, Zhao Liang, Huifang Ding, Ze-yang Zhang, Bixiang J Biomed Sci Review The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain. Generally, TRIM proteins function as E3 ligases to facilitate specific proteasomal degradation of target proteins. In addition, E3 ligase independent functions of TRIM protein were also reported. In hepatocellular carcinoma, expressions of TRIM proteins are both regulated by genetic and epigenetic mechanisms. TRIM proteins regulate multiple biological activities and signaling cascades. And TRIM proteins influence hallmarks of HCC. This review systematically demonstrates the versatile roles of TRIM proteins in HCC and helps us better understand the molecular mechanism of the development and progression of HCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12929-022-00854-7. BioMed Central 2022-09-13 /pmc/articles/PMC9469581/ /pubmed/36100865 http://dx.doi.org/10.1186/s12929-022-00854-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Lu, Kan
Pan, Yonglong
Huang, Zhao
Liang, Huifang
Ding, Ze-yang
Zhang, Bixiang
TRIM proteins in hepatocellular carcinoma
title TRIM proteins in hepatocellular carcinoma
title_full TRIM proteins in hepatocellular carcinoma
title_fullStr TRIM proteins in hepatocellular carcinoma
title_full_unstemmed TRIM proteins in hepatocellular carcinoma
title_short TRIM proteins in hepatocellular carcinoma
title_sort trim proteins in hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469581/
https://www.ncbi.nlm.nih.gov/pubmed/36100865
http://dx.doi.org/10.1186/s12929-022-00854-7
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AT lianghuifang trimproteinsinhepatocellularcarcinoma
AT dingzeyang trimproteinsinhepatocellularcarcinoma
AT zhangbixiang trimproteinsinhepatocellularcarcinoma

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