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Genetic and Biochemical Characterization of Halogenation and Drug Transportation Genes Encoded in the Albofungin Biosynthetic Gene Cluster

Albofungin, a hexacyclic aromatic natural product, exhibits broad-spectrum antimicrobial activity. Its biosynthesis, regulation, and resistance remain elusive. Here, we report the albofungin (abf) biosynthetic gene cluster (BGC) from its producing strain Streptomyces tumemacerans JCM5050. The nascen...

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Detalles Bibliográficos
Autores principales:	Wang, Zhe-Chong, Lo, I-Wen, Lin, Kuan-Hung, Cheng, An Ning, Zadeh, Saeid Malek, Huang, Yen-Hua, Li, Tsung-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Enzymology and Protein Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469721/ https://www.ncbi.nlm.nih.gov/pubmed/36000868 http://dx.doi.org/10.1128/aem.00806-22

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