Research progress on the pharmacological effects of matrine

Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action may be (1) regulation of cancer cell invasion, migration, proliferation, and cell cycle to inhibit tumor growth;...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Yanan, Xu, Lu, Cai, Qihan, Wang, Mengmeng, Wang, Xinliang, Wang, Siming, Ni, Zhiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469773/
https://www.ncbi.nlm.nih.gov/pubmed/36110092
http://dx.doi.org/10.3389/fnins.2022.977374
_version_ 1784788707508748288
author Sun, Yanan
Xu, Lu
Cai, Qihan
Wang, Mengmeng
Wang, Xinliang
Wang, Siming
Ni, Zhiyu
author_facet Sun, Yanan
Xu, Lu
Cai, Qihan
Wang, Mengmeng
Wang, Xinliang
Wang, Siming
Ni, Zhiyu
author_sort Sun, Yanan
collection PubMed
description Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action may be (1) regulation of cancer cell invasion, migration, proliferation, and cell cycle to inhibit tumor growth; (2) reduction of oxidized low-density lipoprotein and advanced glycation end products from the source by exerting anti-inflammatory and antioxidant effects; (3) protection of brain damage and cortical neurons by regulating apoptosis; (4) restoration of the intestinal barrier and regulation of the intestinal microbiota. This article aims to explore matrine’s therapeutic potential by summarizing comprehensive information on matrine’s pharmacology, toxicity, and bioavailability.
format Online
Article
Text
id pubmed-9469773
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94697732022-09-14 Research progress on the pharmacological effects of matrine Sun, Yanan Xu, Lu Cai, Qihan Wang, Mengmeng Wang, Xinliang Wang, Siming Ni, Zhiyu Front Neurosci Neuroscience Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action may be (1) regulation of cancer cell invasion, migration, proliferation, and cell cycle to inhibit tumor growth; (2) reduction of oxidized low-density lipoprotein and advanced glycation end products from the source by exerting anti-inflammatory and antioxidant effects; (3) protection of brain damage and cortical neurons by regulating apoptosis; (4) restoration of the intestinal barrier and regulation of the intestinal microbiota. This article aims to explore matrine’s therapeutic potential by summarizing comprehensive information on matrine’s pharmacology, toxicity, and bioavailability. Frontiers Media S.A. 2022-08-23 /pmc/articles/PMC9469773/ /pubmed/36110092 http://dx.doi.org/10.3389/fnins.2022.977374 Text en Copyright © 2022 Sun, Xu, Cai, Wang, Wang, Wang and Ni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sun, Yanan
Xu, Lu
Cai, Qihan
Wang, Mengmeng
Wang, Xinliang
Wang, Siming
Ni, Zhiyu
Research progress on the pharmacological effects of matrine
title Research progress on the pharmacological effects of matrine
title_full Research progress on the pharmacological effects of matrine
title_fullStr Research progress on the pharmacological effects of matrine
title_full_unstemmed Research progress on the pharmacological effects of matrine
title_short Research progress on the pharmacological effects of matrine
title_sort research progress on the pharmacological effects of matrine
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469773/
https://www.ncbi.nlm.nih.gov/pubmed/36110092
http://dx.doi.org/10.3389/fnins.2022.977374
work_keys_str_mv AT sunyanan researchprogressonthepharmacologicaleffectsofmatrine
AT xulu researchprogressonthepharmacologicaleffectsofmatrine
AT caiqihan researchprogressonthepharmacologicaleffectsofmatrine
AT wangmengmeng researchprogressonthepharmacologicaleffectsofmatrine
AT wangxinliang researchprogressonthepharmacologicaleffectsofmatrine
AT wangsiming researchprogressonthepharmacologicaleffectsofmatrine
AT nizhiyu researchprogressonthepharmacologicaleffectsofmatrine

Ejemplares similares