Cargando…

Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders

The etiologies of several cardiovascular, inflammatory, neurological, hereditary disorders, cancer, and infectious diseases have implicated changes in the genetic set up or genetic mutations as the root cause. Nucleic acid based therapeutics (NBTs) is a new class of biologics that are known to regul...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Pranav, Lalan, Manisha, Barve, Kalyani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469903/
https://www.ncbi.nlm.nih.gov/pubmed/36110526
http://dx.doi.org/10.3389/fphar.2022.974666
_version_ 1784788735952420864
author Shah, Pranav
Lalan, Manisha
Barve, Kalyani
author_facet Shah, Pranav
Lalan, Manisha
Barve, Kalyani
author_sort Shah, Pranav
collection PubMed
description The etiologies of several cardiovascular, inflammatory, neurological, hereditary disorders, cancer, and infectious diseases have implicated changes in the genetic set up or genetic mutations as the root cause. Nucleic acid based therapeutics (NBTs) is a new class of biologics that are known to regulate gene expression at the transcriptional and post-transcriptional level. The NBTs include oligonucleotides, nucleosides, antisense RNA, small interfering RNAs, micro RNA etc. In recent times, this new category of biologics has found enormous potential in the management of cardiovascular, inflammatory, neurological disorders, cancer, infectious diseases and organ transplantation. However, the delivery of NBTs is highly challenging in terms of target specificity (intracellular delivery), mononuclear phagocyte system uptake, stability and biodistribution. Additionally, management of the above mentioned disorders require regular and intrusive therapy making non-invasive routes preferable in comparison to invasive routes like parenteral. The nasal route is garnering focus in delivery of NBTs to the brain in the management of several CNS disorders due to the associated merits such as non-invasiveness, possibility of chronic delivery, improved patient compliance, avoidance of hepatic and gastrointestinal metabolism as well as ability to bypass the BBB. Hence in recent times, this route has been sought by the reserachers as an alternative to parenteral therapy for the delivery of several NBTs. This review shall focus on an array of NBTs delivered through nasal route, their challenges, applications and opportunities. The novel delivery systems for incorporating NBTs; their targeting strategies shall be critically reviewed. The challenges towards regulatory approvals and commercialization shall also be discussed at large. Comparison of learnings derived from the success and barriers in nasal delivery of NBTs will help in identification of futuristic opportunities for their translation from bench to bedside.
format Online
Article
Text
id pubmed-9469903
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94699032022-09-14 Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders Shah, Pranav Lalan, Manisha Barve, Kalyani Front Pharmacol Pharmacology The etiologies of several cardiovascular, inflammatory, neurological, hereditary disorders, cancer, and infectious diseases have implicated changes in the genetic set up or genetic mutations as the root cause. Nucleic acid based therapeutics (NBTs) is a new class of biologics that are known to regulate gene expression at the transcriptional and post-transcriptional level. The NBTs include oligonucleotides, nucleosides, antisense RNA, small interfering RNAs, micro RNA etc. In recent times, this new category of biologics has found enormous potential in the management of cardiovascular, inflammatory, neurological disorders, cancer, infectious diseases and organ transplantation. However, the delivery of NBTs is highly challenging in terms of target specificity (intracellular delivery), mononuclear phagocyte system uptake, stability and biodistribution. Additionally, management of the above mentioned disorders require regular and intrusive therapy making non-invasive routes preferable in comparison to invasive routes like parenteral. The nasal route is garnering focus in delivery of NBTs to the brain in the management of several CNS disorders due to the associated merits such as non-invasiveness, possibility of chronic delivery, improved patient compliance, avoidance of hepatic and gastrointestinal metabolism as well as ability to bypass the BBB. Hence in recent times, this route has been sought by the reserachers as an alternative to parenteral therapy for the delivery of several NBTs. This review shall focus on an array of NBTs delivered through nasal route, their challenges, applications and opportunities. The novel delivery systems for incorporating NBTs; their targeting strategies shall be critically reviewed. The challenges towards regulatory approvals and commercialization shall also be discussed at large. Comparison of learnings derived from the success and barriers in nasal delivery of NBTs will help in identification of futuristic opportunities for their translation from bench to bedside. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9469903/ /pubmed/36110526 http://dx.doi.org/10.3389/fphar.2022.974666 Text en Copyright © 2022 Shah, Lalan and Barve. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Shah, Pranav
Lalan, Manisha
Barve, Kalyani
Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders
title Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders
title_full Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders
title_fullStr Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders
title_full_unstemmed Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders
title_short Intranasal delivery: An attractive route for the administration of nucleic acid based therapeutics for CNS disorders
title_sort intranasal delivery: an attractive route for the administration of nucleic acid based therapeutics for cns disorders
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469903/
https://www.ncbi.nlm.nih.gov/pubmed/36110526
http://dx.doi.org/10.3389/fphar.2022.974666
work_keys_str_mv AT shahpranav intranasaldeliveryanattractiveroutefortheadministrationofnucleicacidbasedtherapeuticsforcnsdisorders
AT lalanmanisha intranasaldeliveryanattractiveroutefortheadministrationofnucleicacidbasedtherapeuticsforcnsdisorders
AT barvekalyani intranasaldeliveryanattractiveroutefortheadministrationofnucleicacidbasedtherapeuticsforcnsdisorders