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Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia

In recent years reported cases of Buruli ulcer, caused by Mycobacterium ulcerans, have increased substantially in Victoria, Australia, with the epidemic also expanding geographically. To develop an understanding of how M. ulcerans circulates in the environment and transmits to humans we analyzed env...

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Autores principales: Blasdell, Kim R., McNamara, Bridgette, O’Brien, Daniel P., Tachedjian, Mary, Boyd, Victoria, Dunn, Michael, Mee, Peter T., Clayton, Simone, Gaburro, Julie, Smith, Ina, Gibney, Katherine B., Tay, Ee Laine, Hobbs, Emma C., Waidyatillake, Nilakshi, Lynch, Stacey E., Stinear, Timothy P., Athan, Eugene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469944/
https://www.ncbi.nlm.nih.gov/pubmed/36099259
http://dx.doi.org/10.1371/journal.pone.0274627
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author Blasdell, Kim R.
McNamara, Bridgette
O’Brien, Daniel P.
Tachedjian, Mary
Boyd, Victoria
Dunn, Michael
Mee, Peter T.
Clayton, Simone
Gaburro, Julie
Smith, Ina
Gibney, Katherine B.
Tay, Ee Laine
Hobbs, Emma C.
Waidyatillake, Nilakshi
Lynch, Stacey E.
Stinear, Timothy P.
Athan, Eugene
author_facet Blasdell, Kim R.
McNamara, Bridgette
O’Brien, Daniel P.
Tachedjian, Mary
Boyd, Victoria
Dunn, Michael
Mee, Peter T.
Clayton, Simone
Gaburro, Julie
Smith, Ina
Gibney, Katherine B.
Tay, Ee Laine
Hobbs, Emma C.
Waidyatillake, Nilakshi
Lynch, Stacey E.
Stinear, Timothy P.
Athan, Eugene
author_sort Blasdell, Kim R.
collection PubMed
description In recent years reported cases of Buruli ulcer, caused by Mycobacterium ulcerans, have increased substantially in Victoria, Australia, with the epidemic also expanding geographically. To develop an understanding of how M. ulcerans circulates in the environment and transmits to humans we analyzed environmental samples collected from 115 properties of recent Buruli ulcer cases and from 115 postcode-matched control properties, for the presence of M. ulcerans. Environmental factors associated with increased odds of M. ulcerans presence at a property included certain native plant species and native vegetation in general, more alkaline soil, lower altitude, the presence of common ringtail possums (Pseudocheirus peregrinus) and overhead powerlines. However, only overhead powerlines and the absence of the native plant Melaleuca lanceolata were associated with Buruli ulcer case properties. Samples positive for M. ulcerans were more likely to be found at case properties and were associated with detections of M. ulcerans in ringtail possum feces, supporting the hypothesis that M. ulcerans is zoonotic, with ringtail possums the strongest reservoir host candidate. However, the disparity in environmental risk factors associated with M. ulcerans positive properties versus case properties indicates the involvement of human behavior or the influence of other environmental factors in disease acquisition that requires further study.
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spelling pubmed-94699442022-09-14 Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia Blasdell, Kim R. McNamara, Bridgette O’Brien, Daniel P. Tachedjian, Mary Boyd, Victoria Dunn, Michael Mee, Peter T. Clayton, Simone Gaburro, Julie Smith, Ina Gibney, Katherine B. Tay, Ee Laine Hobbs, Emma C. Waidyatillake, Nilakshi Lynch, Stacey E. Stinear, Timothy P. Athan, Eugene PLoS One Research Article In recent years reported cases of Buruli ulcer, caused by Mycobacterium ulcerans, have increased substantially in Victoria, Australia, with the epidemic also expanding geographically. To develop an understanding of how M. ulcerans circulates in the environment and transmits to humans we analyzed environmental samples collected from 115 properties of recent Buruli ulcer cases and from 115 postcode-matched control properties, for the presence of M. ulcerans. Environmental factors associated with increased odds of M. ulcerans presence at a property included certain native plant species and native vegetation in general, more alkaline soil, lower altitude, the presence of common ringtail possums (Pseudocheirus peregrinus) and overhead powerlines. However, only overhead powerlines and the absence of the native plant Melaleuca lanceolata were associated with Buruli ulcer case properties. Samples positive for M. ulcerans were more likely to be found at case properties and were associated with detections of M. ulcerans in ringtail possum feces, supporting the hypothesis that M. ulcerans is zoonotic, with ringtail possums the strongest reservoir host candidate. However, the disparity in environmental risk factors associated with M. ulcerans positive properties versus case properties indicates the involvement of human behavior or the influence of other environmental factors in disease acquisition that requires further study. Public Library of Science 2022-09-13 /pmc/articles/PMC9469944/ /pubmed/36099259 http://dx.doi.org/10.1371/journal.pone.0274627 Text en © 2022 Blasdell et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Blasdell, Kim R.
McNamara, Bridgette
O’Brien, Daniel P.
Tachedjian, Mary
Boyd, Victoria
Dunn, Michael
Mee, Peter T.
Clayton, Simone
Gaburro, Julie
Smith, Ina
Gibney, Katherine B.
Tay, Ee Laine
Hobbs, Emma C.
Waidyatillake, Nilakshi
Lynch, Stacey E.
Stinear, Timothy P.
Athan, Eugene
Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia
title Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia
title_full Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia
title_fullStr Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia
title_full_unstemmed Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia
title_short Environmental risk factors associated with the presence of Mycobacterium ulcerans in Victoria, Australia
title_sort environmental risk factors associated with the presence of mycobacterium ulcerans in victoria, australia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469944/
https://www.ncbi.nlm.nih.gov/pubmed/36099259
http://dx.doi.org/10.1371/journal.pone.0274627
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