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An integrative systems biology approach to overcome venetoclax resistance in acute myeloid leukemia
The over-expression of the Bcl-2 protein is a common feature of many solid cancers and hematological malignancies, and it is typically associated with poor prognosis and resistance to chemotherapy. Bcl-2-specific inhibitors, such as venetoclax, have recently been approved for the treatment of chroni...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469948/ https://www.ncbi.nlm.nih.gov/pubmed/36099249 http://dx.doi.org/10.1371/journal.pcbi.1010439 |