Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable...

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Autores principales: Wang, Qianwen, Wu, Kangze, Zhang, Xuzhao, Liu, Yang, Sun, Zhouyi, Wei, Shumei, Zhang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469986/
https://www.ncbi.nlm.nih.gov/pubmed/36110965
http://dx.doi.org/10.3389/fonc.2022.951062
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author Wang, Qianwen
Wu, Kangze
Zhang, Xuzhao
Liu, Yang
Sun, Zhouyi
Wei, Shumei
Zhang, Bo
author_facet Wang, Qianwen
Wu, Kangze
Zhang, Xuzhao
Liu, Yang
Sun, Zhouyi
Wei, Shumei
Zhang, Bo
author_sort Wang, Qianwen
collection PubMed
description Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable and non-special, which are akin to those of tumors of the hepatobiliary and pancreatic systems. The overall prognosis and management of PHPBL differ from those of other tumors in the hepatobiliary system and pancreas. Proper diagnosis and prompt treatment are essential for improving clinical outcomes. Due to its rarity, the optimal treatment has not been issued. However, combination chemotherapy is considered as a standard treatment for them. This review provides an overview of the pathogenesis, diagnosis, pathology, and management of PHPBL and offers clinicians the diagnosis and management schedule for PHPBL.
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spelling pubmed-94699862022-09-14 Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management Wang, Qianwen Wu, Kangze Zhang, Xuzhao Liu, Yang Sun, Zhouyi Wei, Shumei Zhang, Bo Front Oncol Oncology Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable and non-special, which are akin to those of tumors of the hepatobiliary and pancreatic systems. The overall prognosis and management of PHPBL differ from those of other tumors in the hepatobiliary system and pancreas. Proper diagnosis and prompt treatment are essential for improving clinical outcomes. Due to its rarity, the optimal treatment has not been issued. However, combination chemotherapy is considered as a standard treatment for them. This review provides an overview of the pathogenesis, diagnosis, pathology, and management of PHPBL and offers clinicians the diagnosis and management schedule for PHPBL. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9469986/ /pubmed/36110965 http://dx.doi.org/10.3389/fonc.2022.951062 Text en Copyright © 2022 Wang, Wu, Zhang, Liu, Sun, Wei and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Qianwen
Wu, Kangze
Zhang, Xuzhao
Liu, Yang
Sun, Zhouyi
Wei, Shumei
Zhang, Bo
Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management
title Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management
title_full Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management
title_fullStr Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management
title_full_unstemmed Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management
title_short Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management
title_sort primary hepatopancreatobiliary lymphoma: pathogenesis, diagnosis, and management
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9469986/
https://www.ncbi.nlm.nih.gov/pubmed/36110965
http://dx.doi.org/10.3389/fonc.2022.951062
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