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Glycopeptoid nanospheres: glycosylation-induced coacervation of poly(sarcosine)

Conjugation of maltopentaose to water-soluble homo-poly(sarcosine) induced self-association and formed nanospheres (−150 nm) in water although homo-poly(sarcosine) was water-soluble and did not form any aggregates. Fluorescent probe experiments showed that the spheres were non-ionic glycopeptoid coa...

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Detalles Bibliográficos
Autores principales: Okuno, Yota, Nishimura, Tomoki, Sasaki, Yoshihiro, Akiyoshi, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470024/
https://www.ncbi.nlm.nih.gov/pubmed/36133351
http://dx.doi.org/10.1039/d2na00218c
Descripción
Sumario:Conjugation of maltopentaose to water-soluble homo-poly(sarcosine) induced self-association and formed nanospheres (−150 nm) in water although homo-poly(sarcosine) was water-soluble and did not form any aggregates. Fluorescent probe experiments showed that the spheres were non-ionic glycopeptoid coacervate-like particles with both hydrophobic and hydrophilic domains inside.