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A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer

Photothermal therapy (PTT) is a safe and efficient anti-tumor treatment. A photothermal agent (PTA) with good biocompatibility and strong photothermal properties is of great importance for PTT. In this study, near-infrared (NIR) excitable clinical indocyanine green (ICG) was utilized as a PTA and fu...

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Autores principales: Du, Zhong, Ma, Rong, Chen, Shuang, Fan, Huimin, Heng, Youqiang, Yan, Ting, Alimu, Gulinigaer, Zhu, Lijun, Zhang, Xueliang, Alifu, Nuernisha, Ma, Cailing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470054/
https://www.ncbi.nlm.nih.gov/pubmed/36133329
http://dx.doi.org/10.1039/d2na00341d
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author Du, Zhong
Ma, Rong
Chen, Shuang
Fan, Huimin
Heng, Youqiang
Yan, Ting
Alimu, Gulinigaer
Zhu, Lijun
Zhang, Xueliang
Alifu, Nuernisha
Ma, Cailing
author_facet Du, Zhong
Ma, Rong
Chen, Shuang
Fan, Huimin
Heng, Youqiang
Yan, Ting
Alimu, Gulinigaer
Zhu, Lijun
Zhang, Xueliang
Alifu, Nuernisha
Ma, Cailing
author_sort Du, Zhong
collection PubMed
description Photothermal therapy (PTT) is a safe and efficient anti-tumor treatment. A photothermal agent (PTA) with good biocompatibility and strong photothermal properties is of great importance for PTT. In this study, near-infrared (NIR) excitable clinical indocyanine green (ICG) was utilized as a PTA and further encapsulated by another PTA polydopamine (PDA) to form highly stable and efficient ICG@PDA nanoparticles (NPs). Then the ICG@PDA NPs were modified with methoxy polyethylene glycol amine (mPEG(2000)-NH(2)) to form biocompatible ICG@PDA@PEG NPs. ICG@PDA@PEG NPs showed good water solubility and a spherical shape with an average size of 140 nm. Furthermore, the photothermal properties of ICG@PDA@PEG NPs were studied and excellent photothermal performance with a photothermal conversion efficiency of 43.7% under 808 nm laser irradiation was achieved. Then, the PTT properties of ICG@PDA@PEG NPs were confirmed on HeLa cells with an efficiency of 86.1%. Meanwhile, the in vivo biocompatibility and toxicity of ICG@PDA@PEG NPs were evaluated. No apparent in vivo toxicity was observed in 24 hours and 7 days. Next, in vivo PTT analysis was conducted for cervical tumor-bearing nude mice under 808 nm laser excitation. It showed a good anti-tumor effect in vivo. Thus, ICG@PDA@PEG NPs exhibited great potential for safe and efficient photothermal therapy in anti-tumor therapy.
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spelling pubmed-94700542022-09-20 A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer Du, Zhong Ma, Rong Chen, Shuang Fan, Huimin Heng, Youqiang Yan, Ting Alimu, Gulinigaer Zhu, Lijun Zhang, Xueliang Alifu, Nuernisha Ma, Cailing Nanoscale Adv Chemistry Photothermal therapy (PTT) is a safe and efficient anti-tumor treatment. A photothermal agent (PTA) with good biocompatibility and strong photothermal properties is of great importance for PTT. In this study, near-infrared (NIR) excitable clinical indocyanine green (ICG) was utilized as a PTA and further encapsulated by another PTA polydopamine (PDA) to form highly stable and efficient ICG@PDA nanoparticles (NPs). Then the ICG@PDA NPs were modified with methoxy polyethylene glycol amine (mPEG(2000)-NH(2)) to form biocompatible ICG@PDA@PEG NPs. ICG@PDA@PEG NPs showed good water solubility and a spherical shape with an average size of 140 nm. Furthermore, the photothermal properties of ICG@PDA@PEG NPs were studied and excellent photothermal performance with a photothermal conversion efficiency of 43.7% under 808 nm laser irradiation was achieved. Then, the PTT properties of ICG@PDA@PEG NPs were confirmed on HeLa cells with an efficiency of 86.1%. Meanwhile, the in vivo biocompatibility and toxicity of ICG@PDA@PEG NPs were evaluated. No apparent in vivo toxicity was observed in 24 hours and 7 days. Next, in vivo PTT analysis was conducted for cervical tumor-bearing nude mice under 808 nm laser excitation. It showed a good anti-tumor effect in vivo. Thus, ICG@PDA@PEG NPs exhibited great potential for safe and efficient photothermal therapy in anti-tumor therapy. RSC 2022-08-11 /pmc/articles/PMC9470054/ /pubmed/36133329 http://dx.doi.org/10.1039/d2na00341d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Du, Zhong
Ma, Rong
Chen, Shuang
Fan, Huimin
Heng, Youqiang
Yan, Ting
Alimu, Gulinigaer
Zhu, Lijun
Zhang, Xueliang
Alifu, Nuernisha
Ma, Cailing
A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer
title A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer
title_full A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer
title_fullStr A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer
title_full_unstemmed A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer
title_short A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer
title_sort highly efficient polydopamine encapsulated clinical icg theranostic nanoplatform for enhanced photothermal therapy of cervical cancer
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470054/
https://www.ncbi.nlm.nih.gov/pubmed/36133329
http://dx.doi.org/10.1039/d2na00341d
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