Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis( )

Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decre...

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Autores principales: Walker, N F, Karim, F, Moosa, M Y S, Moodley, S, Mazibuko, M, Khan, K, Sterling, T R, van der Heijden, Y F, Grant, A D, Elkington, P T, Pym, A, Leslie, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470104/
https://www.ncbi.nlm.nih.gov/pubmed/35510939
http://dx.doi.org/10.1093/infdis/jiac160
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author Walker, N F
Karim, F
Moosa, M Y S
Moodley, S
Mazibuko, M
Khan, K
Sterling, T R
van der Heijden, Y F
Grant, A D
Elkington, P T
Pym, A
Leslie, A
author_facet Walker, N F
Karim, F
Moosa, M Y S
Moodley, S
Mazibuko, M
Khan, K
Sterling, T R
van der Heijden, Y F
Grant, A D
Elkington, P T
Pym, A
Leslie, A
author_sort Walker, N F
collection PubMed
description Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity.
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spelling pubmed-94701042022-09-14 Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis( ) Walker, N F Karim, F Moosa, M Y S Moodley, S Mazibuko, M Khan, K Sterling, T R van der Heijden, Y F Grant, A D Elkington, P T Pym, A Leslie, A J Infect Dis Brief Report Current methods for tuberculosis treatment monitoring are suboptimal. We evaluated plasma matrix metalloproteinase (MMP) and procollagen III N-terminal propeptide concentrations before and during tuberculosis treatment as biomarkers. Plasma MMP-1, MMP-8, and MMP-10 concentrations significantly decreased during treatment. Plasma MMP-8 was increased in sputum Mycobacterium tuberculosis culture–positive relative to culture-negative participants, before (median, 4993 pg/mL [interquartile range, 2542–9188] vs 698 [218–4060] pg/mL, respectively; P = .004) and after (3650 [1214–3888] vs 720 [551–1321] pg/mL; P = .008) 6 months of tuberculosis treatment. Consequently, plasma MMP-8 is a potential biomarker to enhance tuberculosis treatment monitoring and screen for possible culture positivity. Oxford University Press 2022-05-01 /pmc/articles/PMC9470104/ /pubmed/35510939 http://dx.doi.org/10.1093/infdis/jiac160 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Walker, N F
Karim, F
Moosa, M Y S
Moodley, S
Mazibuko, M
Khan, K
Sterling, T R
van der Heijden, Y F
Grant, A D
Elkington, P T
Pym, A
Leslie, A
Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis( )
title Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis( )
title_full Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis( )
title_fullStr Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis( )
title_full_unstemmed Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis( )
title_short Elevated Plasma Matrix Metalloproteinase 8 Associates With Sputum Culture Positivity in Pulmonary Tuberculosis( )
title_sort elevated plasma matrix metalloproteinase 8 associates with sputum culture positivity in pulmonary tuberculosis( )
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470104/
https://www.ncbi.nlm.nih.gov/pubmed/35510939
http://dx.doi.org/10.1093/infdis/jiac160
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