Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications

The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received special attention because of its function in the development and progression of cardiovascular disease. Numerous investigations have been performed over the past decades to explore the function of the CCL2-CCR2 sig...

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Autores principales: Zhang, Haixia, Yang, Ke, Chen, Feng, Liu, Qianqian, Ni, Jingyu, Cao, Weilong, Hua, Yunqing, He, Feng, Liu, Zhihao, Li, Lan, Fan, Guanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470149/
https://www.ncbi.nlm.nih.gov/pubmed/36110847
http://dx.doi.org/10.3389/fimmu.2022.975367
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author Zhang, Haixia
Yang, Ke
Chen, Feng
Liu, Qianqian
Ni, Jingyu
Cao, Weilong
Hua, Yunqing
He, Feng
Liu, Zhihao
Li, Lan
Fan, Guanwei
author_facet Zhang, Haixia
Yang, Ke
Chen, Feng
Liu, Qianqian
Ni, Jingyu
Cao, Weilong
Hua, Yunqing
He, Feng
Liu, Zhihao
Li, Lan
Fan, Guanwei
author_sort Zhang, Haixia
collection PubMed
description The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received special attention because of its function in the development and progression of cardiovascular disease. Numerous investigations have been performed over the past decades to explore the function of the CCL2-CCR2 signaling axis in cardiovascular disease. Laboratory data on the CCL2-CCR2 axis for cardiovascular disease have shown satisfactory outcomes, yet its clinical translation remains challenging. In this article, we describe the mechanisms of action of the CCL2-CCR2 axis in the development and evolution of cardiovascular diseases including heart failure, atherosclerosis and coronary atherosclerotic heart disease, hypertension and myocardial disease. Laboratory and clinical data on the use of the CCL2-CCR2 pathway as a targeted therapy for cardiovascular diseases are summarized. The potential of the CCL2-CCR2 axis in the treatment of cardiovascular diseases is explored.
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spelling pubmed-94701492022-09-14 Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications Zhang, Haixia Yang, Ke Chen, Feng Liu, Qianqian Ni, Jingyu Cao, Weilong Hua, Yunqing He, Feng Liu, Zhihao Li, Lan Fan, Guanwei Front Immunol Immunology The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received special attention because of its function in the development and progression of cardiovascular disease. Numerous investigations have been performed over the past decades to explore the function of the CCL2-CCR2 signaling axis in cardiovascular disease. Laboratory data on the CCL2-CCR2 axis for cardiovascular disease have shown satisfactory outcomes, yet its clinical translation remains challenging. In this article, we describe the mechanisms of action of the CCL2-CCR2 axis in the development and evolution of cardiovascular diseases including heart failure, atherosclerosis and coronary atherosclerotic heart disease, hypertension and myocardial disease. Laboratory and clinical data on the use of the CCL2-CCR2 pathway as a targeted therapy for cardiovascular diseases are summarized. The potential of the CCL2-CCR2 axis in the treatment of cardiovascular diseases is explored. Frontiers Media S.A. 2022-08-30 /pmc/articles/PMC9470149/ /pubmed/36110847 http://dx.doi.org/10.3389/fimmu.2022.975367 Text en Copyright © 2022 Zhang, Yang, Chen, Liu, Ni, Cao, Hua, He, Liu, Li and Fan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Haixia
Yang, Ke
Chen, Feng
Liu, Qianqian
Ni, Jingyu
Cao, Weilong
Hua, Yunqing
He, Feng
Liu, Zhihao
Li, Lan
Fan, Guanwei
Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
title Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
title_full Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
title_fullStr Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
title_full_unstemmed Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
title_short Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications
title_sort role of the ccl2-ccr2 axis in cardiovascular disease: pathogenesis and clinical implications
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470149/
https://www.ncbi.nlm.nih.gov/pubmed/36110847
http://dx.doi.org/10.3389/fimmu.2022.975367
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