Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

Plasmodium falciparum, the causative agent of malaria, remains a global health threat as parasites continue to develop resistance to antimalarial drugs used throughout the world. Accordingly, drugs with novel modes of action are desperately required to combat malaria. P. falciparum parasites infect...

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Detalles Bibliográficos
Autores principales: Edgar, Rebecca CS, Siddiqui, Ghizal, Hjerrild, Katheryn, Malcolm, Tess R, Vinh, Natalie B, Webb, Chaille T, Holmes, Clare, MacRaild, Christopher A, Chernih, Hope C, Suen, Willy W, Counihan, Natalie A, Creek, Darren J, Scammells, Peter J, McGowan, Sheena, de Koning-Ward, Tania F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470162/
https://www.ncbi.nlm.nih.gov/pubmed/36097817
http://dx.doi.org/10.7554/eLife.80813

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