Cargando…

Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function

The locus coeruleus (LC), a nucleus in the pons of the brainstem, plays a significant role in attention and cognitive control. Here, we use an adapted auditory oddball paradigm and measured the pupil dilation response, to provide a marker of LC activity in humans. In Experiment 1, we show event-rela...

Descripción completa

Detalles Bibliográficos
Autores principales: Cole, Laura, Lightman, Stafford, Clark, Rosie, Gilchrist, Iain D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470248/
https://www.ncbi.nlm.nih.gov/pubmed/36100024
http://dx.doi.org/10.1098/rspb.2022.1545
_version_ 1784788801564966912
author Cole, Laura
Lightman, Stafford
Clark, Rosie
Gilchrist, Iain D.
author_facet Cole, Laura
Lightman, Stafford
Clark, Rosie
Gilchrist, Iain D.
author_sort Cole, Laura
collection PubMed
description The locus coeruleus (LC), a nucleus in the pons of the brainstem, plays a significant role in attention and cognitive control. Here, we use an adapted auditory oddball paradigm and measured the pupil dilation response, to provide a marker of LC activity in humans. In Experiment 1, we show event-related pupil responses to rare auditory events which were further elevated by task relevant. In Experiment 2, by asking participants to silently count the number of oddballs, we demonstrated that the task-relevance elevation was not a result of the generation or execution of the manual response. In Experiment 3, we observed two separate effects of reward on the pupil response. First, we found an overall increase in pupil area in the high compared to the low-reward blocks: a sustained effect reminiscent of the tonic changes that occur in LC. Second, we found elevated event-related pupil responses to behaviourally relevant stimuli in the high-reward condition compared with the low-reward condition, consistent with phasic changes in LC in response to a stimulus. These results highlight the complexity of the relationship between the pupil response and reward, and the inferred role of LC in both top-down and bottom-up cognitive control.
format Online
Article
Text
id pubmed-9470248
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Royal Society
record_format MEDLINE/PubMed
spelling pubmed-94702482022-09-15 Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function Cole, Laura Lightman, Stafford Clark, Rosie Gilchrist, Iain D. Proc Biol Sci Neuroscience and Cognition The locus coeruleus (LC), a nucleus in the pons of the brainstem, plays a significant role in attention and cognitive control. Here, we use an adapted auditory oddball paradigm and measured the pupil dilation response, to provide a marker of LC activity in humans. In Experiment 1, we show event-related pupil responses to rare auditory events which were further elevated by task relevant. In Experiment 2, by asking participants to silently count the number of oddballs, we demonstrated that the task-relevance elevation was not a result of the generation or execution of the manual response. In Experiment 3, we observed two separate effects of reward on the pupil response. First, we found an overall increase in pupil area in the high compared to the low-reward blocks: a sustained effect reminiscent of the tonic changes that occur in LC. Second, we found elevated event-related pupil responses to behaviourally relevant stimuli in the high-reward condition compared with the low-reward condition, consistent with phasic changes in LC in response to a stimulus. These results highlight the complexity of the relationship between the pupil response and reward, and the inferred role of LC in both top-down and bottom-up cognitive control. The Royal Society 2022-09-14 2022-09-14 /pmc/articles/PMC9470248/ /pubmed/36100024 http://dx.doi.org/10.1098/rspb.2022.1545 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Neuroscience and Cognition
Cole, Laura
Lightman, Stafford
Clark, Rosie
Gilchrist, Iain D.
Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function
title Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function
title_full Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function
title_fullStr Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function
title_full_unstemmed Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function
title_short Tonic and phasic effects of reward on the pupil: implications for locus coeruleus function
title_sort tonic and phasic effects of reward on the pupil: implications for locus coeruleus function
topic Neuroscience and Cognition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470248/
https://www.ncbi.nlm.nih.gov/pubmed/36100024
http://dx.doi.org/10.1098/rspb.2022.1545
work_keys_str_mv AT colelaura tonicandphasiceffectsofrewardonthepupilimplicationsforlocuscoeruleusfunction
AT lightmanstafford tonicandphasiceffectsofrewardonthepupilimplicationsforlocuscoeruleusfunction
AT clarkrosie tonicandphasiceffectsofrewardonthepupilimplicationsforlocuscoeruleusfunction
AT gilchristiaind tonicandphasiceffectsofrewardonthepupilimplicationsforlocuscoeruleusfunction