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Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models
BACKGROUND: Probiotics are known to improve atopic dermatitis (AD) by inhibiting T helper 2 (Th2)-related reactions, restoring the Th2/T helper1 (Th1) cytokine ratio. The most popular probiotic is Lactiplantibacillus plantarum (L. plantarum), which is widely used in the food and pharmaceutical indus...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470305/ https://www.ncbi.nlm.nih.gov/pubmed/36110182 http://dx.doi.org/10.1155/2022/4520433 |
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author | Kim, Su-Young Lee, Jung Ok Kim, Yu-Jin Jang, You Na Lee, Jung Min Park, A. Yeon Yoo, Kwang-Ho Kim, Beom Joon |
author_facet | Kim, Su-Young Lee, Jung Ok Kim, Yu-Jin Jang, You Na Lee, Jung Min Park, A. Yeon Yoo, Kwang-Ho Kim, Beom Joon |
author_sort | Kim, Su-Young |
collection | PubMed |
description | BACKGROUND: Probiotics are known to improve atopic dermatitis (AD) by inhibiting T helper 2 (Th2)-related reactions, restoring the Th2/T helper1 (Th1) cytokine ratio. The most popular probiotic is Lactiplantibacillus plantarum (L. plantarum), which is widely used in the food and pharmaceutical industries. L. plantarum APsulloc 331261 (GTB1) used in this study was isolated from green tea. MATERIALS AND METHODS: The effectiveness of oral GTB1 administration in improving AD was evaluated by visual evaluation, comparison of the lymph node sizes and spleen weights, histological evaluation, RT-qPCR, ELISA, and IHC analysis in the mouse model. RESULTS: GTB1 improved AD symptoms, reduced epidermal thickness and mast cell numbers, decreased lymph node size and the spleen weight, increased filaggrin and loricrin protein levels, downregulated Th2 expression, and upregulated Th1 expression in a colony-forming unit-dependent manner. CONCLUSION: Oral administration of GTB1 isolated from green tea (Camellia sinensis) improved the AD symptoms, reduced hypersensitivity reaction, and increased the skin barrier function. Finally, it is involved in AD improvement by restoring the Th2/Th1 cytokine balance. |
format | Online Article Text |
id | pubmed-9470305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94703052022-09-14 Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models Kim, Su-Young Lee, Jung Ok Kim, Yu-Jin Jang, You Na Lee, Jung Min Park, A. Yeon Yoo, Kwang-Ho Kim, Beom Joon Evid Based Complement Alternat Med Research Article BACKGROUND: Probiotics are known to improve atopic dermatitis (AD) by inhibiting T helper 2 (Th2)-related reactions, restoring the Th2/T helper1 (Th1) cytokine ratio. The most popular probiotic is Lactiplantibacillus plantarum (L. plantarum), which is widely used in the food and pharmaceutical industries. L. plantarum APsulloc 331261 (GTB1) used in this study was isolated from green tea. MATERIALS AND METHODS: The effectiveness of oral GTB1 administration in improving AD was evaluated by visual evaluation, comparison of the lymph node sizes and spleen weights, histological evaluation, RT-qPCR, ELISA, and IHC analysis in the mouse model. RESULTS: GTB1 improved AD symptoms, reduced epidermal thickness and mast cell numbers, decreased lymph node size and the spleen weight, increased filaggrin and loricrin protein levels, downregulated Th2 expression, and upregulated Th1 expression in a colony-forming unit-dependent manner. CONCLUSION: Oral administration of GTB1 isolated from green tea (Camellia sinensis) improved the AD symptoms, reduced hypersensitivity reaction, and increased the skin barrier function. Finally, it is involved in AD improvement by restoring the Th2/Th1 cytokine balance. Hindawi 2022-09-06 /pmc/articles/PMC9470305/ /pubmed/36110182 http://dx.doi.org/10.1155/2022/4520433 Text en Copyright © 2022 Su-Young Kim et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kim, Su-Young Lee, Jung Ok Kim, Yu-Jin Jang, You Na Lee, Jung Min Park, A. Yeon Yoo, Kwang-Ho Kim, Beom Joon Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models |
title | Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models |
title_full | Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models |
title_fullStr | Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models |
title_full_unstemmed | Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models |
title_short | Effects of Oral Administration of Lactiplantibacillus Plantarum APsulloc 331261 (GTB1(TM)) Isolated from Green Tea on Atopic Dermatitis (AD)-like Skin Lesion Mouse Models |
title_sort | effects of oral administration of lactiplantibacillus plantarum apsulloc 331261 (gtb1(tm)) isolated from green tea on atopic dermatitis (ad)-like skin lesion mouse models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470305/ https://www.ncbi.nlm.nih.gov/pubmed/36110182 http://dx.doi.org/10.1155/2022/4520433 |
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