Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm

Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-1β has been implicated in various pathological conditions including myeloproliferative neoplasms (MPNs). Here we show that IL-1β serum levels and expression of IL-1 receptors on hematopoietic progenitors and stem...

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Detalles Bibliográficos
Autores principales: Rai, Shivam, Grockowiak, Elodie, Hansen, Nils, Luque Paz, Damien, Stoll, Cedric B., Hao-Shen, Hui, Mild-Schneider, Gabriele, Dirnhofer, Stefan, Farady, Christopher J., Méndez-Ferrer, Simón, Skoda, Radek C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470591/
https://www.ncbi.nlm.nih.gov/pubmed/36100613
http://dx.doi.org/10.1038/s41467-022-32927-4

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