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Rational inhibitor design for Pseudomonas aeruginosa salicylate adenylation enzyme PchD

Pseudomonas aeruginosa is an increasingly antibiotic-resistant pathogen that causes severe lung infections, burn wound infections, and diabetic foot infections. P. aeruginosa produces the siderophore pyochelin through the use of a non-ribosomal peptide synthetase (NRPS) biosynthetic pathway. Targeti...

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Detalles Bibliográficos
Autores principales:	Shelton, Catherine L., Meneely, Kathleen M., Ronnebaum, Trey A., Chilton, Annemarie S., Riley, Andrew P., Prisinzano, Thomas E., Lamb, Audrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470617/ https://www.ncbi.nlm.nih.gov/pubmed/35513576 http://dx.doi.org/10.1007/s00775-022-01941-8

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