Protein kinase C targeting of luminal (T-47D), luminal/HER2-positive (BT474), and triple negative (HCC1806) breast cancer cells in-vitro with AEB071 (Sotrastaurin) is efficient but mediated by subtype specific molecular effects

PURPOSE: Protein kinase C (PKC) plays a pivotal role in malignant cell proliferation, apoptosis, invasiveness and migration. However, its exploitation as therapeutic target in breast cancer has been merely explored. Here were evaluated the AEB071 (Sotrastaurin™) treatment efficiency of breast cancer...

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Detalles Bibliográficos
Autores principales: Albert, Veruschka, Piendl, Gerhard, Yousseff, Dali, Lammert, Hedwig, Hummel, Michael, Ortmann, Olaf, Jagla, Wolfgang, Gaumann, Andreas, Wege, Anja K., Brockhoff, Gero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Gynecologic Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470618/
https://www.ncbi.nlm.nih.gov/pubmed/35298675
http://dx.doi.org/10.1007/s00404-022-06434-2

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