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The role of obesity and bariatric surgery-induced weight loss in breast cancer

Obesity is a complex metabolic condition considered a worldwide public health crisis, and a deeper mechanistic understanding of obesity-associated diseases is urgently needed. Obesity comorbidities include many associated cancers and are estimated to account for 20% of female cancer deaths in the US...

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Autores principales: Bohm, Margaret S., Sipe, Laura M., Pye, Madeline E., Davis, Matthew J., Pierre, Joseph F., Makowski, Liza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470652/
https://www.ncbi.nlm.nih.gov/pubmed/35870055
http://dx.doi.org/10.1007/s10555-022-10050-6
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author Bohm, Margaret S.
Sipe, Laura M.
Pye, Madeline E.
Davis, Matthew J.
Pierre, Joseph F.
Makowski, Liza
author_facet Bohm, Margaret S.
Sipe, Laura M.
Pye, Madeline E.
Davis, Matthew J.
Pierre, Joseph F.
Makowski, Liza
author_sort Bohm, Margaret S.
collection PubMed
description Obesity is a complex metabolic condition considered a worldwide public health crisis, and a deeper mechanistic understanding of obesity-associated diseases is urgently needed. Obesity comorbidities include many associated cancers and are estimated to account for 20% of female cancer deaths in the USA. Breast cancer, in particular, is associated with obesity and is the focus of this review. The exact causal links between obesity and breast cancer remain unclear. Still, interactions have emerged between body mass index, tumor molecular subtype, genetic background, and environmental factors that strongly suggest obesity influences the risk and progression of certain breast cancers. Supportive preclinical research uses various diet-induced obesity models to demonstrate that weight loss, via dietary interventions or changes in energy expenditure, reduces the onset or progression of breast cancers. Ongoing and future studies are now aimed at elucidating the underpinning mechanisms behind weight-loss-driven observations to improve therapy and outcomes in patients with breast cancer and reduce risk. This review aims to summarize the rapidly emerging literature on obesity and weight loss strategies with a focused discussion of bariatric surgery in both clinical and preclinical studies detailing the complex interactions between metabolism, immune response, and immunotherapy in the setting of obesity and breast cancer.
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spelling pubmed-94706522022-09-15 The role of obesity and bariatric surgery-induced weight loss in breast cancer Bohm, Margaret S. Sipe, Laura M. Pye, Madeline E. Davis, Matthew J. Pierre, Joseph F. Makowski, Liza Cancer Metastasis Rev Article Obesity is a complex metabolic condition considered a worldwide public health crisis, and a deeper mechanistic understanding of obesity-associated diseases is urgently needed. Obesity comorbidities include many associated cancers and are estimated to account for 20% of female cancer deaths in the USA. Breast cancer, in particular, is associated with obesity and is the focus of this review. The exact causal links between obesity and breast cancer remain unclear. Still, interactions have emerged between body mass index, tumor molecular subtype, genetic background, and environmental factors that strongly suggest obesity influences the risk and progression of certain breast cancers. Supportive preclinical research uses various diet-induced obesity models to demonstrate that weight loss, via dietary interventions or changes in energy expenditure, reduces the onset or progression of breast cancers. Ongoing and future studies are now aimed at elucidating the underpinning mechanisms behind weight-loss-driven observations to improve therapy and outcomes in patients with breast cancer and reduce risk. This review aims to summarize the rapidly emerging literature on obesity and weight loss strategies with a focused discussion of bariatric surgery in both clinical and preclinical studies detailing the complex interactions between metabolism, immune response, and immunotherapy in the setting of obesity and breast cancer. Springer US 2022-07-23 2022 /pmc/articles/PMC9470652/ /pubmed/35870055 http://dx.doi.org/10.1007/s10555-022-10050-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Bohm, Margaret S.
Sipe, Laura M.
Pye, Madeline E.
Davis, Matthew J.
Pierre, Joseph F.
Makowski, Liza
The role of obesity and bariatric surgery-induced weight loss in breast cancer
title The role of obesity and bariatric surgery-induced weight loss in breast cancer
title_full The role of obesity and bariatric surgery-induced weight loss in breast cancer
title_fullStr The role of obesity and bariatric surgery-induced weight loss in breast cancer
title_full_unstemmed The role of obesity and bariatric surgery-induced weight loss in breast cancer
title_short The role of obesity and bariatric surgery-induced weight loss in breast cancer
title_sort role of obesity and bariatric surgery-induced weight loss in breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470652/
https://www.ncbi.nlm.nih.gov/pubmed/35870055
http://dx.doi.org/10.1007/s10555-022-10050-6
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