Soluble guanylate cyclase activator BAY 54–6544 improves vasomotor function and survival in an accelerated ageing mouse model

DNA damage is a causative factor in ageing of the vasculature and other organs. One of the most important vascular ageing features is reduced nitric oxide (NO)soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signaling. We hypothesized that the restoration of NO‐sGC‐cGMP signalin...

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Detalles Bibliográficos
Autores principales: Ataei Ataabadi, Ehsan, Golshiri, Keivan, Jüttner, Annika A., de Vries, René, Van den Berg‐Garrelds, Ingrid, Nagtzaam, Nicole M. A., Khan, Hina N., Leijten, Frank P. J., Brandt, Renata M. C., Dik, Willem A., van der Pluijm, Ingrid, Danser, A. H. Jan, Sandner, Peter, Roks, Anton J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470884/
https://www.ncbi.nlm.nih.gov/pubmed/36029161
http://dx.doi.org/10.1111/acel.13683

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