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Cohort study of long working hours and increase in blood high‐sensitivity C‐reactive protein (hsCRP) concentration: Mechanisms of overwork and cardiovascular disease
OBJECTIVES: We aimed to find evidence of the inflammation‐mediated mechanism by which long working hours contribute to cardiovascular disease (CVD). METHODS: This cohort study was performed in 56 953 Korean adults free of CVD who underwent a comprehensive screening examination and were followed for...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470891/ https://www.ncbi.nlm.nih.gov/pubmed/36101013 http://dx.doi.org/10.1002/1348-9585.12359 |
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author | Lee, Woncheol Yim, Hyeon Woo Lee, Yeseong |
author_facet | Lee, Woncheol Yim, Hyeon Woo Lee, Yeseong |
author_sort | Lee, Woncheol |
collection | PubMed |
description | OBJECTIVES: We aimed to find evidence of the inflammation‐mediated mechanism by which long working hours contribute to cardiovascular disease (CVD). METHODS: This cohort study was performed in 56 953 Korean adults free of CVD who underwent a comprehensive screening examination and were followed for up to 7 years. An increase in blood high‐sensitivity C‐reactive protein (hsCRP) of 1 mg/L or more at the follow‐up visit was defined as an incidence. The average weekly working hours in the past year were categorized as ≤40, 41–52, 53–60, and ≥60 h per week. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using generalized estimating equations to calculate the risk of an incidental increase of hsCRP. RESULTS: Participants with longer working hours had a higher incidence of hsCRP. Multivariable‐adjusted ORs (95% CIs) of incident cases for ≥61 h compared with ≤40 h was 1.69 (1.04–2.75). In subgroup analyses according to sex and the presence of hypertension and diabetes, the risk of hsCRP incidence were highest in the group working more than 61 h in all subgroups, but none of them were statistically significant. CONCLUSIONS: Working hours are independently associated with increased risk of elevated hsCRP in a dose–response relationship. Excessive long‐time work is a risk factor for CVD, and it was found that an increase in hsCRP was associated with the pathogenesis. |
format | Online Article Text |
id | pubmed-9470891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94708912022-09-28 Cohort study of long working hours and increase in blood high‐sensitivity C‐reactive protein (hsCRP) concentration: Mechanisms of overwork and cardiovascular disease Lee, Woncheol Yim, Hyeon Woo Lee, Yeseong J Occup Health Original Articles OBJECTIVES: We aimed to find evidence of the inflammation‐mediated mechanism by which long working hours contribute to cardiovascular disease (CVD). METHODS: This cohort study was performed in 56 953 Korean adults free of CVD who underwent a comprehensive screening examination and were followed for up to 7 years. An increase in blood high‐sensitivity C‐reactive protein (hsCRP) of 1 mg/L or more at the follow‐up visit was defined as an incidence. The average weekly working hours in the past year were categorized as ≤40, 41–52, 53–60, and ≥60 h per week. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using generalized estimating equations to calculate the risk of an incidental increase of hsCRP. RESULTS: Participants with longer working hours had a higher incidence of hsCRP. Multivariable‐adjusted ORs (95% CIs) of incident cases for ≥61 h compared with ≤40 h was 1.69 (1.04–2.75). In subgroup analyses according to sex and the presence of hypertension and diabetes, the risk of hsCRP incidence were highest in the group working more than 61 h in all subgroups, but none of them were statistically significant. CONCLUSIONS: Working hours are independently associated with increased risk of elevated hsCRP in a dose–response relationship. Excessive long‐time work is a risk factor for CVD, and it was found that an increase in hsCRP was associated with the pathogenesis. John Wiley and Sons Inc. 2022-09-13 /pmc/articles/PMC9470891/ /pubmed/36101013 http://dx.doi.org/10.1002/1348-9585.12359 Text en © 2022 The Authors. Journal of Occupational Health published by John Wiley & Sons Australia, Ltd on behalf of The Japan Society for Occupational Health. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Lee, Woncheol Yim, Hyeon Woo Lee, Yeseong Cohort study of long working hours and increase in blood high‐sensitivity C‐reactive protein (hsCRP) concentration: Mechanisms of overwork and cardiovascular disease |
title | Cohort study of long working hours and increase in blood high‐sensitivity C‐reactive protein (hsCRP) concentration: Mechanisms of overwork and cardiovascular disease |
title_full | Cohort study of long working hours and increase in blood high‐sensitivity C‐reactive protein (hsCRP) concentration: Mechanisms of overwork and cardiovascular disease |
title_fullStr | Cohort study of long working hours and increase in blood high‐sensitivity C‐reactive protein (hsCRP) concentration: Mechanisms of overwork and cardiovascular disease |
title_full_unstemmed | Cohort study of long working hours and increase in blood high‐sensitivity C‐reactive protein (hsCRP) concentration: Mechanisms of overwork and cardiovascular disease |
title_short | Cohort study of long working hours and increase in blood high‐sensitivity C‐reactive protein (hsCRP) concentration: Mechanisms of overwork and cardiovascular disease |
title_sort | cohort study of long working hours and increase in blood high‐sensitivity c‐reactive protein (hscrp) concentration: mechanisms of overwork and cardiovascular disease |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470891/ https://www.ncbi.nlm.nih.gov/pubmed/36101013 http://dx.doi.org/10.1002/1348-9585.12359 |
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