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Emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine

INTRODUCTION: Antidepressants in older people have experienced their increase in medical prescriptions in recent decades whit comorbidity with other pathologies and drug polytherapies. With the use of antidepressants, can be observed side and unwanted effects (e.g. emotional blunting). Vortioxetine...

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Autores principales: Franza, F., Solomita, B., Colucci, A., Perito, M., Pellegrino, F., Buono, G. Del, Tavormina, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471019/
http://dx.doi.org/10.1192/j.eurpsy.2021.875
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author Franza, F.
Solomita, B.
Colucci, A.
Perito, M.
Pellegrino, F.
Buono, G. Del
Tavormina, G.
author_facet Franza, F.
Solomita, B.
Colucci, A.
Perito, M.
Pellegrino, F.
Buono, G. Del
Tavormina, G.
author_sort Franza, F.
collection PubMed
description INTRODUCTION: Antidepressants in older people have experienced their increase in medical prescriptions in recent decades whit comorbidity with other pathologies and drug polytherapies. With the use of antidepressants, can be observed side and unwanted effects (e.g. emotional blunting). Vortioxetine is a new antidepressant agent which promises fewer side effects. OBJECTIVES: To evaluate the clinical efficacy, safety, side effects (e.g emotional blunting) and cognitive profile METHODS: 45 elderly patients affected by MDD (DSM-5) were recruited in our observational study. All patients were treated with vortioxetine for 12 months. Physiological and pathological parameters were collected at baseline (T0), after 3 months (T1), 6 months (T2); 12 months (T3). All patients were administered the following scales: GDS; MMSE; QLi; ODQ. The statistical data were processed with EZAnalyze. RESULTS: 33.33% of patients had a score in the “unlikely depression” GDS group. The ANOVA ODQ “Total” results indicate that at least two of the repeated measures differ significantly. Data of the “antidepressant as cause” dimension are interesting [T0 vs T3 (P-Unadjusted .000; P-Bonferroni .000; T-value 5.687. MMSE scores are indicative of one small but not significant difference. Mean QLIndex scores did not show statistically significant changes, but are indicative of positive changes from the baseline score CONCLUSIONS: Vortioxetine resulted in partial reduction of depression. There was a moderate non-statistically significant increase in body weight, glycidic and lipid profiles. Overall data highlight the importance and role that vortioxetine can have in the management of depressive symptoms in elderly subjects. The handling, effectiveness and reduced side effects of the molecule are emphasized.
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spelling pubmed-94710192022-09-29 Emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine Franza, F. Solomita, B. Colucci, A. Perito, M. Pellegrino, F. Buono, G. Del Tavormina, G. Eur Psychiatry Abstract INTRODUCTION: Antidepressants in older people have experienced their increase in medical prescriptions in recent decades whit comorbidity with other pathologies and drug polytherapies. With the use of antidepressants, can be observed side and unwanted effects (e.g. emotional blunting). Vortioxetine is a new antidepressant agent which promises fewer side effects. OBJECTIVES: To evaluate the clinical efficacy, safety, side effects (e.g emotional blunting) and cognitive profile METHODS: 45 elderly patients affected by MDD (DSM-5) were recruited in our observational study. All patients were treated with vortioxetine for 12 months. Physiological and pathological parameters were collected at baseline (T0), after 3 months (T1), 6 months (T2); 12 months (T3). All patients were administered the following scales: GDS; MMSE; QLi; ODQ. The statistical data were processed with EZAnalyze. RESULTS: 33.33% of patients had a score in the “unlikely depression” GDS group. The ANOVA ODQ “Total” results indicate that at least two of the repeated measures differ significantly. Data of the “antidepressant as cause” dimension are interesting [T0 vs T3 (P-Unadjusted .000; P-Bonferroni .000; T-value 5.687. MMSE scores are indicative of one small but not significant difference. Mean QLIndex scores did not show statistically significant changes, but are indicative of positive changes from the baseline score CONCLUSIONS: Vortioxetine resulted in partial reduction of depression. There was a moderate non-statistically significant increase in body weight, glycidic and lipid profiles. Overall data highlight the importance and role that vortioxetine can have in the management of depressive symptoms in elderly subjects. The handling, effectiveness and reduced side effects of the molecule are emphasized. Cambridge University Press 2021-08-13 /pmc/articles/PMC9471019/ http://dx.doi.org/10.1192/j.eurpsy.2021.875 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Franza, F.
Solomita, B.
Colucci, A.
Perito, M.
Pellegrino, F.
Buono, G. Del
Tavormina, G.
Emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine
title Emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine
title_full Emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine
title_fullStr Emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine
title_full_unstemmed Emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine
title_short Emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine
title_sort emotional blunting and cognitive profile in elderly depressed patients in treatment with vortioxetine
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471019/
http://dx.doi.org/10.1192/j.eurpsy.2021.875
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