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Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression
INTRODUCTION: Several studies have shown impaired cytokine status in both patients with depression and chronic heart failure (HF). OBJECTIVES: to study the effect of vortioxetine on the level of pro-inflammatory cytokines: interleukin -1β (IL-1β) and interleukin - 6 (IL-6). METHODS: there were exami...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471139/ http://dx.doi.org/10.1192/j.eurpsy.2021.269 |
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author | Sikora, A. Fedorov, S. Pityk, O. Vynnyk, M. |
author_facet | Sikora, A. Fedorov, S. Pityk, O. Vynnyk, M. |
author_sort | Sikora, A. |
collection | PubMed |
description | INTRODUCTION: Several studies have shown impaired cytokine status in both patients with depression and chronic heart failure (HF). OBJECTIVES: to study the effect of vortioxetine on the level of pro-inflammatory cytokines: interleukin -1β (IL-1β) and interleukin - 6 (IL-6). METHODS: there were examined 80 patients with HF with reduced ejection fraction (HFrEF) of ischemic genesis with functional class (FC) II-III (NYHA), 37 patients were without depression, 43 - with mild or moderate depressive disorders. Those with mild or moderate depressive disorders were divided into 2 subgroups: 21 patients received psychotherapy, 22 patients, in addition to psychotherapy, were prescribed vortioxetine at a dose of 10 mg / day in the morning after meals. The control group consisted of 20 healthy individuals. The level of cytokines in the blood was determined by ELISA method. RESULTS: Patients with CHF have an increase in levels of pro-inflammatory cytokines. Thus, the concentration in the serum of IL-1β was 2.3 times higher than the same indicator in the control group: (56.45 ± 4.17) pg / ml, against (24.71 ± 4.21) pg / ml p <0.001). Depression caused an additional increase in the levels of IL-1β by 13.5% (p <0.05) and IL-6 - by 17.3% (p <0.01). Additional administration of vortioxetine caused a more rapid decrease in blood levels of both IL-1β (HR 0.87 [95% CI 0.72-0.97; p = 0.034]) and IL-6 (HR 0.81 [95% CI 0.68-0.93; p = 0.029]). CONCLUSIONS: Thus, vortioxetine causes a decrease in the concentration of pro-inflammatory cytokines IL-1β and IL-6 in patients with HF and comorbid depression. DISCLOSURE: No significant relationships. |
format | Online Article Text |
id | pubmed-9471139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-94711392022-09-29 Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression Sikora, A. Fedorov, S. Pityk, O. Vynnyk, M. Eur Psychiatry Abstract INTRODUCTION: Several studies have shown impaired cytokine status in both patients with depression and chronic heart failure (HF). OBJECTIVES: to study the effect of vortioxetine on the level of pro-inflammatory cytokines: interleukin -1β (IL-1β) and interleukin - 6 (IL-6). METHODS: there were examined 80 patients with HF with reduced ejection fraction (HFrEF) of ischemic genesis with functional class (FC) II-III (NYHA), 37 patients were without depression, 43 - with mild or moderate depressive disorders. Those with mild or moderate depressive disorders were divided into 2 subgroups: 21 patients received psychotherapy, 22 patients, in addition to psychotherapy, were prescribed vortioxetine at a dose of 10 mg / day in the morning after meals. The control group consisted of 20 healthy individuals. The level of cytokines in the blood was determined by ELISA method. RESULTS: Patients with CHF have an increase in levels of pro-inflammatory cytokines. Thus, the concentration in the serum of IL-1β was 2.3 times higher than the same indicator in the control group: (56.45 ± 4.17) pg / ml, against (24.71 ± 4.21) pg / ml p <0.001). Depression caused an additional increase in the levels of IL-1β by 13.5% (p <0.05) and IL-6 - by 17.3% (p <0.01). Additional administration of vortioxetine caused a more rapid decrease in blood levels of both IL-1β (HR 0.87 [95% CI 0.72-0.97; p = 0.034]) and IL-6 (HR 0.81 [95% CI 0.68-0.93; p = 0.029]). CONCLUSIONS: Thus, vortioxetine causes a decrease in the concentration of pro-inflammatory cytokines IL-1β and IL-6 in patients with HF and comorbid depression. DISCLOSURE: No significant relationships. Cambridge University Press 2021-08-13 /pmc/articles/PMC9471139/ http://dx.doi.org/10.1192/j.eurpsy.2021.269 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Sikora, A. Fedorov, S. Pityk, O. Vynnyk, M. Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression |
title | Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression |
title_full | Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression |
title_fullStr | Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression |
title_full_unstemmed | Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression |
title_short | Effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression |
title_sort | effect of vortioxetine on proinflammatory cytokine levels in patients with heart failure and comorbid depression |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471139/ http://dx.doi.org/10.1192/j.eurpsy.2021.269 |
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