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Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion

BACKGROUND: Unexplained recurrent spontaneous abortion is a serious reproductive problem of unknown etiology. Thyroid peroxidase antibodies (TPO-Ab) may be associated with pregnancy outcomes in unexplained recurrent spontaneous abortion with normal thyroid function. OBJECTIVE: This study aimed to in...

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Autores principales: Liu, Meilan, Wang, Dongyan, Zhu, Liqiong, Yin, Jianlan, Ji, Xiaohui, Zhong, Yilei, Gao, Yuan, Zhang, Jianping, Liu, Yukun, Zhang, Rui, Chen, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471195/
https://www.ncbi.nlm.nih.gov/pubmed/36120428
http://dx.doi.org/10.3389/fendo.2022.966565
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author Liu, Meilan
Wang, Dongyan
Zhu, Liqiong
Yin, Jianlan
Ji, Xiaohui
Zhong, Yilei
Gao, Yuan
Zhang, Jianping
Liu, Yukun
Zhang, Rui
Chen, Hui
author_facet Liu, Meilan
Wang, Dongyan
Zhu, Liqiong
Yin, Jianlan
Ji, Xiaohui
Zhong, Yilei
Gao, Yuan
Zhang, Jianping
Liu, Yukun
Zhang, Rui
Chen, Hui
author_sort Liu, Meilan
collection PubMed
description BACKGROUND: Unexplained recurrent spontaneous abortion is a serious reproductive problem of unknown etiology. Thyroid peroxidase antibodies (TPO-Ab) may be associated with pregnancy outcomes in unexplained recurrent spontaneous abortion with normal thyroid function. OBJECTIVE: This study aimed to investigate the relationship between TPO-Ab and the first trimester miscarriage rate/live birth rate in women of unexplained recurrent spontaneous abortion with normal thyroid function. METHODS: We retrospectively analyzed the clinical data of 297 women who met our strict inclusion criteria, comparing the first trimester miscarriage rate/live birth rate between the TPO-Ab positive and TPO-Ab negative groups. For the same purpose, we also performed subgroup analysis. RESULTS: Of the included women, 76 (25.6%) were TPO-Ab positive, and 221 (74.4%) were negative. First trimester miscarriage rate differed between the two groups (36.8% vs 24.0%, RR = 1.54, 95% CI: 1.05–2.24, P = 0.030). In the younger subgroup (<35 years) and the primary RSA subgroup, First trimester miscarriage rate was also higher in the TPO-Ab positive group (33.3% vs 19.0%, RR = 1.75, 95% CI: 1.07–2.87, P = 0.030; 36.5% vs 21.7%, RR = 1.69, 95% CI: 1.10–2.58, P = 0.020). While the live birth rate was lower in women with TPO-Ab positive, the difference did not reach statistical significance, even in the subgroup analysis. CONCLUSION: Our results suggest that TPO-Ab is associated with first trimester miscarriage rate in euthyroid women with unexplained recurrent spontaneous abortion.
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spelling pubmed-94711952022-09-15 Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion Liu, Meilan Wang, Dongyan Zhu, Liqiong Yin, Jianlan Ji, Xiaohui Zhong, Yilei Gao, Yuan Zhang, Jianping Liu, Yukun Zhang, Rui Chen, Hui Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Unexplained recurrent spontaneous abortion is a serious reproductive problem of unknown etiology. Thyroid peroxidase antibodies (TPO-Ab) may be associated with pregnancy outcomes in unexplained recurrent spontaneous abortion with normal thyroid function. OBJECTIVE: This study aimed to investigate the relationship between TPO-Ab and the first trimester miscarriage rate/live birth rate in women of unexplained recurrent spontaneous abortion with normal thyroid function. METHODS: We retrospectively analyzed the clinical data of 297 women who met our strict inclusion criteria, comparing the first trimester miscarriage rate/live birth rate between the TPO-Ab positive and TPO-Ab negative groups. For the same purpose, we also performed subgroup analysis. RESULTS: Of the included women, 76 (25.6%) were TPO-Ab positive, and 221 (74.4%) were negative. First trimester miscarriage rate differed between the two groups (36.8% vs 24.0%, RR = 1.54, 95% CI: 1.05–2.24, P = 0.030). In the younger subgroup (<35 years) and the primary RSA subgroup, First trimester miscarriage rate was also higher in the TPO-Ab positive group (33.3% vs 19.0%, RR = 1.75, 95% CI: 1.07–2.87, P = 0.030; 36.5% vs 21.7%, RR = 1.69, 95% CI: 1.10–2.58, P = 0.020). While the live birth rate was lower in women with TPO-Ab positive, the difference did not reach statistical significance, even in the subgroup analysis. CONCLUSION: Our results suggest that TPO-Ab is associated with first trimester miscarriage rate in euthyroid women with unexplained recurrent spontaneous abortion. Frontiers Media S.A. 2022-08-31 /pmc/articles/PMC9471195/ /pubmed/36120428 http://dx.doi.org/10.3389/fendo.2022.966565 Text en Copyright © 2022 Liu, Wang, Zhu, Yin, Ji, Zhong, Gao, Zhang, Liu, Zhang and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Liu, Meilan
Wang, Dongyan
Zhu, Liqiong
Yin, Jianlan
Ji, Xiaohui
Zhong, Yilei
Gao, Yuan
Zhang, Jianping
Liu, Yukun
Zhang, Rui
Chen, Hui
Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion
title Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion
title_full Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion
title_fullStr Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion
title_full_unstemmed Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion
title_short Association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion
title_sort association of thyroid peroxidase antibodies with the rate of first-trimester miscarriage in euthyroid women with unexplained recurrent spontaneous abortion
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471195/
https://www.ncbi.nlm.nih.gov/pubmed/36120428
http://dx.doi.org/10.3389/fendo.2022.966565
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