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Dual Fc optimization to increase the cytotoxic activity of a CD19-targeting antibody

Targeting CD19 represents a promising strategy for the therapy of B-cell malignancies. Although non-engineered CD19 antibodies are poorly effective in mediating complement-dependent cytotoxicity (CDC), antibody-dependent cell-mediated cytotoxicity (ADCC) or antibody-dependent cellular phagocytosis (...

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Detalles Bibliográficos
Autores principales:	Gehlert, Carina Lynn, Rahmati, Pegah, Boje, Ammelie Svea, Winterberg, Dorothee, Krohn, Steffen, Theocharis, Thomas, Cappuzzello, Elisa, Lux, Anja, Nimmerjahn, Falk, Ludwig, Ralf J., Lustig, Marta, Rösner, Thies, Valerius, Thomas, Schewe, Denis Martin, Kellner, Christian, Klausz, Katja, Peipp, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471254/ https://www.ncbi.nlm.nih.gov/pubmed/36119088 http://dx.doi.org/10.3389/fimmu.2022.957874

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