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Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation

INTRODUCTION: Use of combined antidepressive treatment included high-frequency rhythmic transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is one of the ways for overcoming of pharmaco-resistance in depressive patients. OBJECTIVES: The aim of the study was th...

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Autores principales: Iznak, E., Iznak, A., Oleichik, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471359/
http://dx.doi.org/10.1192/j.eurpsy.2021.308
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author Iznak, E.
Iznak, A.
Oleichik, I.
author_facet Iznak, E.
Iznak, A.
Oleichik, I.
author_sort Iznak, E.
collection PubMed
description INTRODUCTION: Use of combined antidepressive treatment included high-frequency rhythmic transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is one of the ways for overcoming of pharmaco-resistance in depressive patients. OBJECTIVES: The aim of the study was the search for possible EEG predictors of antidepressive effects of rTMS of the left DLPFC in combined treatment of depression. METHODS: 30 female in-patients (F31.3, F33.0, F33.1, by ICD-10; 20-50 years, mean age 36.9±10.3) with pharmaco-resistant depression were enrolled in the study. Treatment included antidepressants (mainly SSRI) and a 3-week course of rTMS (20 Hz) of the left DLPFC. Correlations between pre-treatment EEG spectral power values, and post-treatment quantitative clinical assessments of patients were analyzed. Responders/non-responders were determined by standard criteria of 50% decrease in HDRS-17 scale total scores after treatment course. RESULTS: Responders (23 out of 30) revealed significant (p<0.05) negative correlations between post-treatment HDRS-17 scores and pre-treatment EEG spectral power in theta-2 (6-8 Hz) and alpha-1 (8-9 Hz) frequency sub-bands in the parietal-occipital-posterior temporal leads. Non-responders (7 out of 30) showed negative correlations between the post-treatment HDRS-17 scores and pre-treatment theta-2 EEG spectral power in the frontal-central-temporal regions of the right hemisphere. CONCLUSIONS: Even brief course of rTMS of the left DLPFC enhances the action of antidepressants, and allows overcoming partially the pharmaco-resistance in depressive patients. Baseline values of theta-2 and alpha-1 EEG spectral power may serve as possible predictors of the effects of combined antidepressive therapy including rTMS. The study supported by RBRF grant No.18-01-00029a. DISCLOSURE: No significant relationships.
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spelling pubmed-94713592022-09-29 Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation Iznak, E. Iznak, A. Oleichik, I. Eur Psychiatry Abstract INTRODUCTION: Use of combined antidepressive treatment included high-frequency rhythmic transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is one of the ways for overcoming of pharmaco-resistance in depressive patients. OBJECTIVES: The aim of the study was the search for possible EEG predictors of antidepressive effects of rTMS of the left DLPFC in combined treatment of depression. METHODS: 30 female in-patients (F31.3, F33.0, F33.1, by ICD-10; 20-50 years, mean age 36.9±10.3) with pharmaco-resistant depression were enrolled in the study. Treatment included antidepressants (mainly SSRI) and a 3-week course of rTMS (20 Hz) of the left DLPFC. Correlations between pre-treatment EEG spectral power values, and post-treatment quantitative clinical assessments of patients were analyzed. Responders/non-responders were determined by standard criteria of 50% decrease in HDRS-17 scale total scores after treatment course. RESULTS: Responders (23 out of 30) revealed significant (p<0.05) negative correlations between post-treatment HDRS-17 scores and pre-treatment EEG spectral power in theta-2 (6-8 Hz) and alpha-1 (8-9 Hz) frequency sub-bands in the parietal-occipital-posterior temporal leads. Non-responders (7 out of 30) showed negative correlations between the post-treatment HDRS-17 scores and pre-treatment theta-2 EEG spectral power in the frontal-central-temporal regions of the right hemisphere. CONCLUSIONS: Even brief course of rTMS of the left DLPFC enhances the action of antidepressants, and allows overcoming partially the pharmaco-resistance in depressive patients. Baseline values of theta-2 and alpha-1 EEG spectral power may serve as possible predictors of the effects of combined antidepressive therapy including rTMS. The study supported by RBRF grant No.18-01-00029a. DISCLOSURE: No significant relationships. Cambridge University Press 2021-08-13 /pmc/articles/PMC9471359/ http://dx.doi.org/10.1192/j.eurpsy.2021.308 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Iznak, E.
Iznak, A.
Oleichik, I.
Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation
title Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation
title_full Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation
title_fullStr Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation
title_full_unstemmed Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation
title_short Baseline EEG-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation
title_sort baseline eeg-correlates of responders/non-responders to combined antidepressive treatment including transcranial magnetic stimulation
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471359/
http://dx.doi.org/10.1192/j.eurpsy.2021.308
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