Cargando…
Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System
Transsynaptic transport is the most accepted proposal to explain the SARS-CoV-2 infection of the CNS. Nevertheless, emerging evidence shows that neurons do not express the SARS-CoV-2 receptor ACE2, which highlights the importance of the blood-brain barrier (BBB) in preventing virus entry to the brai...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Brain and Neural Sciences
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471413/ https://www.ncbi.nlm.nih.gov/pubmed/36050226 http://dx.doi.org/10.5607/en21049 |
_version_ | 1784789069512835072 |
---|---|
author | Rodríguez-Morales, Jahir Guartazaca-Guerrero, Sebastián Rizo-Téllez, Salma A. Viurcos-Sanabria, Rebeca Barrón, Eira Valeria Hernández-Valencia, Aldo F. Nava, Porfirio Escobedo, Galileo Carrillo-Ruiz, José Damián Méndez-García, Lucía A. |
author_facet | Rodríguez-Morales, Jahir Guartazaca-Guerrero, Sebastián Rizo-Téllez, Salma A. Viurcos-Sanabria, Rebeca Barrón, Eira Valeria Hernández-Valencia, Aldo F. Nava, Porfirio Escobedo, Galileo Carrillo-Ruiz, José Damián Méndez-García, Lucía A. |
author_sort | Rodríguez-Morales, Jahir |
collection | PubMed |
description | Transsynaptic transport is the most accepted proposal to explain the SARS-CoV-2 infection of the CNS. Nevertheless, emerging evidence shows that neurons do not express the SARS-CoV-2 receptor ACE2, which highlights the importance of the blood-brain barrier (BBB) in preventing virus entry to the brain. In this study, we examine the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA) and the cytokine profile in cerebrospinal fluids (CSF) from two patients with a brain tumor and COVID-19. To determine the BBB damage, we evaluate the Q- albumin index, which is an indirect parameter to assess the permeability of this structure. The Q-albumin index of the patient with an intraventricular brain tumor suggests that the BBB is undamaged, preventing the passage of SARS-CoV-2 and pro-inflammatory molecules. The development of brain tumors that disrupt the BBB (measured by the Q-albumin index), in this case, a petroclival meningioma (Case 1), allows the free passage of the SARS-CoV-2 virus and probably lets the free transit of pro-inflammatory molecules to the CNS, which leads to a possible activation of the microglia (astrogliosis) and an exacerbated immune response represented by IL-13, IFN-γ, and IL-2 trying to inhibit both the infection and the carcinogenic process. |
format | Online Article Text |
id | pubmed-9471413 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Society for Brain and Neural Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-94714132022-09-19 Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System Rodríguez-Morales, Jahir Guartazaca-Guerrero, Sebastián Rizo-Téllez, Salma A. Viurcos-Sanabria, Rebeca Barrón, Eira Valeria Hernández-Valencia, Aldo F. Nava, Porfirio Escobedo, Galileo Carrillo-Ruiz, José Damián Méndez-García, Lucía A. Exp Neurobiol Case Report Transsynaptic transport is the most accepted proposal to explain the SARS-CoV-2 infection of the CNS. Nevertheless, emerging evidence shows that neurons do not express the SARS-CoV-2 receptor ACE2, which highlights the importance of the blood-brain barrier (BBB) in preventing virus entry to the brain. In this study, we examine the presence of SARS-CoV-2 messenger ribonucleic acid (mRNA) and the cytokine profile in cerebrospinal fluids (CSF) from two patients with a brain tumor and COVID-19. To determine the BBB damage, we evaluate the Q- albumin index, which is an indirect parameter to assess the permeability of this structure. The Q-albumin index of the patient with an intraventricular brain tumor suggests that the BBB is undamaged, preventing the passage of SARS-CoV-2 and pro-inflammatory molecules. The development of brain tumors that disrupt the BBB (measured by the Q-albumin index), in this case, a petroclival meningioma (Case 1), allows the free passage of the SARS-CoV-2 virus and probably lets the free transit of pro-inflammatory molecules to the CNS, which leads to a possible activation of the microglia (astrogliosis) and an exacerbated immune response represented by IL-13, IFN-γ, and IL-2 trying to inhibit both the infection and the carcinogenic process. The Korean Society for Brain and Neural Sciences 2022-08-31 2022-08-31 /pmc/articles/PMC9471413/ /pubmed/36050226 http://dx.doi.org/10.5607/en21049 Text en Copyright © Experimental Neurobiology 2022 https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Rodríguez-Morales, Jahir Guartazaca-Guerrero, Sebastián Rizo-Téllez, Salma A. Viurcos-Sanabria, Rebeca Barrón, Eira Valeria Hernández-Valencia, Aldo F. Nava, Porfirio Escobedo, Galileo Carrillo-Ruiz, José Damián Méndez-García, Lucía A. Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System |
title | Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System |
title_full | Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System |
title_fullStr | Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System |
title_full_unstemmed | Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System |
title_short | Blood-brain Barrier Damage is Pivotal for SARS-CoV-2 Infection to the Central Nervous System |
title_sort | blood-brain barrier damage is pivotal for sars-cov-2 infection to the central nervous system |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471413/ https://www.ncbi.nlm.nih.gov/pubmed/36050226 http://dx.doi.org/10.5607/en21049 |
work_keys_str_mv | AT rodriguezmoralesjahir bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT guartazacaguerrerosebastian bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT rizotellezsalmaa bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT viurcossanabriarebeca bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT barroneiravaleria bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT hernandezvalenciaaldof bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT navaporfirio bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT escobedogalileo bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT carrilloruizjosedamian bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem AT mendezgarcialuciaa bloodbrainbarrierdamageispivotalforsarscov2infectiontothecentralnervoussystem |