Epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis

Epithelioid angiomyolipoma is a rare variant of angiomyolipoma and a part of the microphthalmia transcription factor (MiTF) tumors. We report a case of epithelioid angiomyolipoma of the kidney that occurred in a 40-year-old male. The tumor was composed of sheets of uniform epithelioid cells with cle...

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Detalles Bibliográficos
Autores principales: Shaker, Nada, Wu, Douglas, Parwani, Anil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471470/
https://www.ncbi.nlm.nih.gov/pubmed/36117733
http://dx.doi.org/10.1016/j.eucr.2022.102204
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author Shaker, Nada
Wu, Douglas
Parwani, Anil
author_facet Shaker, Nada
Wu, Douglas
Parwani, Anil
author_sort Shaker, Nada
collection PubMed
description Epithelioid angiomyolipoma is a rare variant of angiomyolipoma and a part of the microphthalmia transcription factor (MiTF) tumors. We report a case of epithelioid angiomyolipoma of the kidney that occurred in a 40-year-old male. The tumor was composed of sheets of uniform epithelioid cells with clear to granular eosinophilic cytoplasm and hyperchromatic nuclei. The tumor extended into the vascular margin and perinephric fat with identified angiolymphatic invasion. Immunohistochemistry showed diffuse staining for HMB45, Melan A, and focal staining for SMA. No expression for EMA, AE1/AE3, CK7, S100, or Desmin was noted. The patient underwent a left nephrectomy with no recurrence.
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spelling pubmed-94714702022-09-15 Epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis Shaker, Nada Wu, Douglas Parwani, Anil Urol Case Rep Oncology Epithelioid angiomyolipoma is a rare variant of angiomyolipoma and a part of the microphthalmia transcription factor (MiTF) tumors. We report a case of epithelioid angiomyolipoma of the kidney that occurred in a 40-year-old male. The tumor was composed of sheets of uniform epithelioid cells with clear to granular eosinophilic cytoplasm and hyperchromatic nuclei. The tumor extended into the vascular margin and perinephric fat with identified angiolymphatic invasion. Immunohistochemistry showed diffuse staining for HMB45, Melan A, and focal staining for SMA. No expression for EMA, AE1/AE3, CK7, S100, or Desmin was noted. The patient underwent a left nephrectomy with no recurrence. Elsevier 2022-09-05 /pmc/articles/PMC9471470/ /pubmed/36117733 http://dx.doi.org/10.1016/j.eucr.2022.102204 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Oncology
Shaker, Nada
Wu, Douglas
Parwani, Anil
Epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis
title Epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis
title_full Epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis
title_fullStr Epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis
title_full_unstemmed Epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis
title_short Epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis
title_sort epithelioid angiomyolipoma of the kidney in an adult male with tuberous sclerosis
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471470/
https://www.ncbi.nlm.nih.gov/pubmed/36117733
http://dx.doi.org/10.1016/j.eucr.2022.102204
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AT parwanianil epithelioidangiomyolipomaofthekidneyinanadultmalewithtuberoussclerosis

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