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High-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water

β-lactam, more specifically carbapenems, are antibiotics used as last resort pharmaceuticals to deal with infections. Despite the medical relevance, they are considered contaminants of emerging concern in water because of their recalcitrance to conventional systems in the municipal wastewater treatm...

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Autores principales: Celis-Llamoca, Kevin, Serna-Galvis, Efraím A., Torres-Palma, Ricardo A., Nieto-Juárez, Jessica I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471477/
https://www.ncbi.nlm.nih.gov/pubmed/36117679
http://dx.doi.org/10.1016/j.mex.2022.101835
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author Celis-Llamoca, Kevin
Serna-Galvis, Efraím A.
Torres-Palma, Ricardo A.
Nieto-Juárez, Jessica I.
author_facet Celis-Llamoca, Kevin
Serna-Galvis, Efraím A.
Torres-Palma, Ricardo A.
Nieto-Juárez, Jessica I.
author_sort Celis-Llamoca, Kevin
collection PubMed
description β-lactam, more specifically carbapenems, are antibiotics used as last resort pharmaceuticals to deal with infections. Despite the medical relevance, they are considered contaminants of emerging concern in water because of their recalcitrance to conventional systems in the municipal wastewater treatment plants. This work aimed to show alternative methods based on the use of high-frequency ultrasound (200-1000 kHz) at a laboratory scale to degrade meropenem (a representative carbapenem antibiotic) in water. The ability of the sonochemical method alone to eliminate meropenem was tested initially. Then, the improvements of degradation by the addition of ferrous iron, or Fe (II) plus UVA light (sono-Fenton, or sono-photo-Fenton methods) were assessed. Finally, the effect of the best ultrasound-based method on the removal of biological activity of meropenem was determined. • Three high-frequency ultrasound processes were applied to degrade meropenem in water. • Sono-photo-Fenton degraded 67% of imipenem at 60 min of treatment and decreased significantly H(2)O(2) accumulation. • Antimicrobial activity was removed after only 30 min of sono-photo-Fenton action.
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spelling pubmed-94714772022-09-15 High-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water Celis-Llamoca, Kevin Serna-Galvis, Efraím A. Torres-Palma, Ricardo A. Nieto-Juárez, Jessica I. MethodsX Method Article β-lactam, more specifically carbapenems, are antibiotics used as last resort pharmaceuticals to deal with infections. Despite the medical relevance, they are considered contaminants of emerging concern in water because of their recalcitrance to conventional systems in the municipal wastewater treatment plants. This work aimed to show alternative methods based on the use of high-frequency ultrasound (200-1000 kHz) at a laboratory scale to degrade meropenem (a representative carbapenem antibiotic) in water. The ability of the sonochemical method alone to eliminate meropenem was tested initially. Then, the improvements of degradation by the addition of ferrous iron, or Fe (II) plus UVA light (sono-Fenton, or sono-photo-Fenton methods) were assessed. Finally, the effect of the best ultrasound-based method on the removal of biological activity of meropenem was determined. • Three high-frequency ultrasound processes were applied to degrade meropenem in water. • Sono-photo-Fenton degraded 67% of imipenem at 60 min of treatment and decreased significantly H(2)O(2) accumulation. • Antimicrobial activity was removed after only 30 min of sono-photo-Fenton action. Elsevier 2022-08-28 /pmc/articles/PMC9471477/ /pubmed/36117679 http://dx.doi.org/10.1016/j.mex.2022.101835 Text en © 2022 The Author(s). Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Method Article
Celis-Llamoca, Kevin
Serna-Galvis, Efraím A.
Torres-Palma, Ricardo A.
Nieto-Juárez, Jessica I.
High-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water
title High-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water
title_full High-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water
title_fullStr High-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water
title_full_unstemmed High-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water
title_short High-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water
title_sort high-frequency ultrasound processes as alternative methods for degrading meropenem antibiotic in water
topic Method Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471477/
https://www.ncbi.nlm.nih.gov/pubmed/36117679
http://dx.doi.org/10.1016/j.mex.2022.101835
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