Long-term antiretroviral therapy initiated in acute HIV infection prevents residual dysfunction of HIV-specific CD8(+) T cells

BACKGROUND: Harnessing CD8(+) T cell responses is being explored to achieve HIV remission. Although HIV-specific CD8(+) T cells become dysfunctional without treatment, antiretroviral therapy (ART) partially restores their function. However, the extent of this recovery under long-term ART is less und...

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Detalles Bibliográficos
Autores principales: Takata, Hiroshi, Kakazu, Juyeon C., Mitchell, Julie L., Kroon, Eugene, Colby, Donn J., Sacdalan, Carlo, Bai, Hongjun, Ehrenberg, Philip K., Geretz, Aviva, Buranapraditkun, Supranee, Pinyakorn, Suteeraporn, Intasan, Jintana, Tipsuk, Somporn, Suttichom, Duanghathai, Prueksakaew, Peeriya, Chalermchai, Thep, Chomchey, Nitiya, Phanuphak, Nittaya, de Souza, Mark, Michael, Nelson L., Robb, Merlin L., Haddad, Elias K., Crowell, Trevor A, Vasan, Sandhya, Valcour, Victor G., Douek, Daniel C., Thomas, Rasmi, Rolland, Morgane, Chomont, Nicolas, Ananworanich, Jintanat, Trautmann, Lydie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471490/
https://www.ncbi.nlm.nih.gov/pubmed/36088683
http://dx.doi.org/10.1016/j.ebiom.2022.104253

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