Drug attitude inventory is relevant to LAI treatment persistence in schizophrenia: Preliminary results

INTRODUCTION: Patients’ attitudes and subjective experience are crucial in the management of severe mental illness, but their practical value is overlooked. OBJECTIVES: To identify predictors of future adherence to LAI antipsychotic maintenance treatment of schizophrenia among socio-demographic, clinical, and psychometric characteristics – including Drug Attitude Inventory-10 (DAI-10) and Subjective Well-being under Neuroleptics short form (SWN-K) scores. METHODS: Retrospective baseline data from 53 clinically stable outpatients with schizophrenia switched from oral to LAI therapy were collected. Patients continuing treatment at the time of analysis (n=29) were compared to those who had discontinued it (n=24). Selected variables were further evaluated in survival analyses. RESULTS: Between-group differences are presented in Table 1 (**: p<0.01; *: p<0.05). [Table: see text] Cox regression analysis included instruction, employment, hospitalisations, PANSS subscales and DAI-10 scores: a protective role against treatment discontinuation was outlined only for employment (HR 0.16; 95%CI 0.05-0.50) and higher DAI-10 scores (HR 0.85; 95%CI 0.78-0.94). DAI-10 scores delineated distinct adherence trajectories (Figure 1). [Figure: see text] CONCLUSIONS: Baseline DAI-10 scores may identify patients at risk of dropout after switching to LAI. DISCLOSURE: No significant relationships.