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How genetics can help diagnosis and treatment in psychiatric conditions
The understanding of the genetic architecture of psychiatric disorders has made significant advances in the last decade and some scientific findings can now be translated into clinical practice. The rise of genetic testing and the awareness of patients and their families motivate psychiatrists to ex...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471788/ http://dx.doi.org/10.1192/j.eurpsy.2021.156 |
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author | Chaumette, B. Laurent-Levinson, C. Almos, P. Degenhardt, F. |
author_facet | Chaumette, B. Laurent-Levinson, C. Almos, P. Degenhardt, F. |
author_sort | Chaumette, B. |
collection | PubMed |
description | The understanding of the genetic architecture of psychiatric disorders has made significant advances in the last decade and some scientific findings can now be translated into clinical practice. The rise of genetic testing and the awareness of patients and their families motivate psychiatrists to examine this approach. The COST Action EnGagE (CA17130) is promoting these developments in Europe. Whereas the findings of common variants are the domain of research, screening for rare variants at the genome-wide level is already applicable in clinical practice. It is now possible to return meaningful results to the individual to help him/her understanding the disease and the comorbidities, to guide treatment and to perform genetic counseling. In this presentation, we will give meaningful examples for psychiatric practice. For instance, around one-third of the patients diagnosed with autism spectrum disorder can benefit from a molecular diagnosis (fragile X syndrome, SHANK3 deletion…). Microdeletion or microduplication may explain a fraction of schizophrenic cases (e.g. del22q11). Identification of rare variants causing the disease may decrease the stigma and feeling of guilt often reported by patients and families. This could also help to detect and manage other comorbidities. It is expected that treatment guidelines and clinical trials would be developed in the near future for patients carrying a rare variant, opening the way to personalized psychiatry. Finally, this effort has a huge impact on the family, by enhancing genetic counseling in psychiatry. The rise of psychiatric genetics might align our field more closely with the other medical specialties. DISCLOSURE: No significant relationships. |
format | Online Article Text |
id | pubmed-9471788 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-94717882022-09-29 How genetics can help diagnosis and treatment in psychiatric conditions Chaumette, B. Laurent-Levinson, C. Almos, P. Degenhardt, F. Eur Psychiatry Abstract The understanding of the genetic architecture of psychiatric disorders has made significant advances in the last decade and some scientific findings can now be translated into clinical practice. The rise of genetic testing and the awareness of patients and their families motivate psychiatrists to examine this approach. The COST Action EnGagE (CA17130) is promoting these developments in Europe. Whereas the findings of common variants are the domain of research, screening for rare variants at the genome-wide level is already applicable in clinical practice. It is now possible to return meaningful results to the individual to help him/her understanding the disease and the comorbidities, to guide treatment and to perform genetic counseling. In this presentation, we will give meaningful examples for psychiatric practice. For instance, around one-third of the patients diagnosed with autism spectrum disorder can benefit from a molecular diagnosis (fragile X syndrome, SHANK3 deletion…). Microdeletion or microduplication may explain a fraction of schizophrenic cases (e.g. del22q11). Identification of rare variants causing the disease may decrease the stigma and feeling of guilt often reported by patients and families. This could also help to detect and manage other comorbidities. It is expected that treatment guidelines and clinical trials would be developed in the near future for patients carrying a rare variant, opening the way to personalized psychiatry. Finally, this effort has a huge impact on the family, by enhancing genetic counseling in psychiatry. The rise of psychiatric genetics might align our field more closely with the other medical specialties. DISCLOSURE: No significant relationships. Cambridge University Press 2021-08-13 /pmc/articles/PMC9471788/ http://dx.doi.org/10.1192/j.eurpsy.2021.156 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Chaumette, B. Laurent-Levinson, C. Almos, P. Degenhardt, F. How genetics can help diagnosis and treatment in psychiatric conditions |
title | How genetics can help diagnosis and treatment in psychiatric conditions |
title_full | How genetics can help diagnosis and treatment in psychiatric conditions |
title_fullStr | How genetics can help diagnosis and treatment in psychiatric conditions |
title_full_unstemmed | How genetics can help diagnosis and treatment in psychiatric conditions |
title_short | How genetics can help diagnosis and treatment in psychiatric conditions |
title_sort | how genetics can help diagnosis and treatment in psychiatric conditions |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471788/ http://dx.doi.org/10.1192/j.eurpsy.2021.156 |
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