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Terbinafine and antidepressants: Potential risk of medication induced mania
INTRODUCTION: Mood destabilization and induced manic episodes are well-known phenomenon under antidepressant medications. However, even with a cautious introduction of antidepressants, it’s important to be aware of possible pharmacological interactions. Terbinafine is a known inhibitor of CYP2D6, a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471882/ http://dx.doi.org/10.1192/j.eurpsy.2021.528 |
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author | Barbosa, P. Nombora, O. Monteiro, J. Ribeiro, L. |
author_facet | Barbosa, P. Nombora, O. Monteiro, J. Ribeiro, L. |
author_sort | Barbosa, P. |
collection | PubMed |
description | INTRODUCTION: Mood destabilization and induced manic episodes are well-known phenomenon under antidepressant medications. However, even with a cautious introduction of antidepressants, it’s important to be aware of possible pharmacological interactions. Terbinafine is a known inhibitor of CYP2D6, a major hepatic metabolizer of a full list of antidepressant medications, and so capable of raising their serum levels and potentiating their side effects. OBJECTIVES: With this case report we aim to emphasize the importance of cautious usage of Terbinafine when combined with antidepressant medications. METHODS: We present a clinical case of an induced first manic episode after the introduction of Terbinafine in a patient under antidepressant medication and a qualitative review on the topic, using PubMed database. RESULTS: A 66-year-old woman, with an history of Major Depressive Disorder, previously medicated with Venlafaxine 75mg/day and Mirtazapine 30mg/day, was brought to the emergency department because of psychomotor agitation. She also had an history of seasonal fluctuating mood, although never fulfilling the criteria for Bipolar Disorder. At admission, her clinical status was compatible with a manic episode. This episode followed two months after the initiation of Terbinafine for onychomycosis. CONCLUSIONS: There are few studies that have shown antidepressant toxicity mediated by an interaction with Terbinafine. As far as we know this is the first case of induced mania after the introduction of Terbinafine. Therefore, it is important to remind that Terbinafine is a potential interacting agent when combined with psychotropic medications. |
format | Online Article Text |
id | pubmed-9471882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-94718822022-09-29 Terbinafine and antidepressants: Potential risk of medication induced mania Barbosa, P. Nombora, O. Monteiro, J. Ribeiro, L. Eur Psychiatry Abstract INTRODUCTION: Mood destabilization and induced manic episodes are well-known phenomenon under antidepressant medications. However, even with a cautious introduction of antidepressants, it’s important to be aware of possible pharmacological interactions. Terbinafine is a known inhibitor of CYP2D6, a major hepatic metabolizer of a full list of antidepressant medications, and so capable of raising their serum levels and potentiating their side effects. OBJECTIVES: With this case report we aim to emphasize the importance of cautious usage of Terbinafine when combined with antidepressant medications. METHODS: We present a clinical case of an induced first manic episode after the introduction of Terbinafine in a patient under antidepressant medication and a qualitative review on the topic, using PubMed database. RESULTS: A 66-year-old woman, with an history of Major Depressive Disorder, previously medicated with Venlafaxine 75mg/day and Mirtazapine 30mg/day, was brought to the emergency department because of psychomotor agitation. She also had an history of seasonal fluctuating mood, although never fulfilling the criteria for Bipolar Disorder. At admission, her clinical status was compatible with a manic episode. This episode followed two months after the initiation of Terbinafine for onychomycosis. CONCLUSIONS: There are few studies that have shown antidepressant toxicity mediated by an interaction with Terbinafine. As far as we know this is the first case of induced mania after the introduction of Terbinafine. Therefore, it is important to remind that Terbinafine is a potential interacting agent when combined with psychotropic medications. Cambridge University Press 2021-08-13 /pmc/articles/PMC9471882/ http://dx.doi.org/10.1192/j.eurpsy.2021.528 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Barbosa, P. Nombora, O. Monteiro, J. Ribeiro, L. Terbinafine and antidepressants: Potential risk of medication induced mania |
title | Terbinafine and antidepressants: Potential risk of medication induced mania |
title_full | Terbinafine and antidepressants: Potential risk of medication induced mania |
title_fullStr | Terbinafine and antidepressants: Potential risk of medication induced mania |
title_full_unstemmed | Terbinafine and antidepressants: Potential risk of medication induced mania |
title_short | Terbinafine and antidepressants: Potential risk of medication induced mania |
title_sort | terbinafine and antidepressants: potential risk of medication induced mania |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471882/ http://dx.doi.org/10.1192/j.eurpsy.2021.528 |
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