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Sphingolipid metabolism and signaling in cardiovascular diseases
Sphingolipids are a structural component of the cell membrane, derived from sphingosine, an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations that lead to the formation of biologically active compounds, which play a crucial role in the essential pathways of cellu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471951/ https://www.ncbi.nlm.nih.gov/pubmed/36119733 http://dx.doi.org/10.3389/fcvm.2022.915961 |
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author | Borodzicz-Jażdżyk, Sonia Jażdżyk, Piotr Łysik, Wojciech Cudnoch-Jȩdrzejewska, Agnieszka Czarzasta, Katarzyna |
author_facet | Borodzicz-Jażdżyk, Sonia Jażdżyk, Piotr Łysik, Wojciech Cudnoch-Jȩdrzejewska, Agnieszka Czarzasta, Katarzyna |
author_sort | Borodzicz-Jażdżyk, Sonia |
collection | PubMed |
description | Sphingolipids are a structural component of the cell membrane, derived from sphingosine, an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations that lead to the formation of biologically active compounds, which play a crucial role in the essential pathways of cellular signaling, proliferation, maturation, and death. The constantly growing number of experimental and clinical studies emphasizes the pivotal role of sphingolipids in the pathophysiology of cardiovascular diseases, including, in particular, ischemic heart disease, hypertension, heart failure, and stroke. It has also been proven that altering the sphingolipid metabolism has cardioprotective properties in cardiac pathologies, including myocardial infarction. Recent studies suggest that selected sphingolipids may serve as valuable biomarkers useful in the prognosis of cardiovascular disorders in clinical practice. This review aims to provide an overview of the current knowledge of sphingolipid metabolism and signaling in cardiovascular diseases. |
format | Online Article Text |
id | pubmed-9471951 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94719512022-09-15 Sphingolipid metabolism and signaling in cardiovascular diseases Borodzicz-Jażdżyk, Sonia Jażdżyk, Piotr Łysik, Wojciech Cudnoch-Jȩdrzejewska, Agnieszka Czarzasta, Katarzyna Front Cardiovasc Med Cardiovascular Medicine Sphingolipids are a structural component of the cell membrane, derived from sphingosine, an amino alcohol. Its sphingoid base undergoes various types of enzymatic transformations that lead to the formation of biologically active compounds, which play a crucial role in the essential pathways of cellular signaling, proliferation, maturation, and death. The constantly growing number of experimental and clinical studies emphasizes the pivotal role of sphingolipids in the pathophysiology of cardiovascular diseases, including, in particular, ischemic heart disease, hypertension, heart failure, and stroke. It has also been proven that altering the sphingolipid metabolism has cardioprotective properties in cardiac pathologies, including myocardial infarction. Recent studies suggest that selected sphingolipids may serve as valuable biomarkers useful in the prognosis of cardiovascular disorders in clinical practice. This review aims to provide an overview of the current knowledge of sphingolipid metabolism and signaling in cardiovascular diseases. Frontiers Media S.A. 2022-08-31 /pmc/articles/PMC9471951/ /pubmed/36119733 http://dx.doi.org/10.3389/fcvm.2022.915961 Text en Copyright © 2022 Borodzicz-Jażdżyk, Jażdżyk, Łysik, Cudnoch-Jȩdrzejewska and Czarzasta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Borodzicz-Jażdżyk, Sonia Jażdżyk, Piotr Łysik, Wojciech Cudnoch-Jȩdrzejewska, Agnieszka Czarzasta, Katarzyna Sphingolipid metabolism and signaling in cardiovascular diseases |
title | Sphingolipid metabolism and signaling in cardiovascular diseases |
title_full | Sphingolipid metabolism and signaling in cardiovascular diseases |
title_fullStr | Sphingolipid metabolism and signaling in cardiovascular diseases |
title_full_unstemmed | Sphingolipid metabolism and signaling in cardiovascular diseases |
title_short | Sphingolipid metabolism and signaling in cardiovascular diseases |
title_sort | sphingolipid metabolism and signaling in cardiovascular diseases |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9471951/ https://www.ncbi.nlm.nih.gov/pubmed/36119733 http://dx.doi.org/10.3389/fcvm.2022.915961 |
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